Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK043706-13
Application #
6634978
Study Section
Metabolism Study Section (MET)
Program Officer
Laughlin, Maren R
Project Start
1991-04-01
Project End
2005-03-31
Budget Start
2003-04-01
Budget End
2004-03-31
Support Year
13
Fiscal Year
2003
Total Cost
$413,002
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Physiology
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Kraft, Guillaume; Coate, Katie C; Winnick, Jason J et al. (2017) Glucagon's effect on liver protein metabolism in vivo. Am J Physiol Endocrinol Metab 313:E263-E272
Winnick, Jason J; An, Zhibo; Kraft, Guillaume et al. (2013) Liver glycogen loading dampens glycogen synthesis seen in response to either hyperinsulinemia or intraportal glucose infusion. Diabetes 62:96-101
Moore, Mary Courtney; Coate, Katie C; Winnick, Jason J et al. (2012) Regulation of hepatic glucose uptake and storage in vivo. Adv Nutr 3:286-94
Kraft, Guillaume; Coate, Katie C; Dardevet, Dominique et al. (2012) Portal glucose delivery stimulates muscle but not liver protein metabolism. Am J Physiol Endocrinol Metab 303:E1202-11
An, Zhibo; Winnick, Jason J; Moore, Mary C et al. (2012) A cyclic guanosine monophosphate-dependent pathway can regulate net hepatic glucose uptake in vivo. Diabetes 61:2433-41
Johnson, Kathryn M S; Farmer, Tiffany; Schurr, Kathleen et al. (2011) Endogenously released GLP-1 is not sufficient to alter postprandial glucose regulation in the dog. Endocrine 39:229-34
Winnick, Jason J; An, Zhibo; Ramnanan, Christopher J et al. (2011) Hepatic glycogen supercompensation activates AMP-activated protein kinase, impairs insulin signaling, and reduces glycogen deposition in the liver. Diabetes 60:398-407
An, Zhibo; Winnick, Jason J; Farmer, Ben et al. (2010) A soluble guanylate cyclase-dependent mechanism is involved in the regulation of net hepatic glucose uptake by nitric oxide in vivo. Diabetes 59:2999-3007
An, Zhibo; Moore, Mary C; Winnick, Jason J et al. (2009) Portal infusion of escitalopram enhances hepatic glucose disposal in conscious dogs. Eur J Pharmacol 607:251-7
Winnick, Jason J; An, Zhibo; Moore, Mary Courtney et al. (2009) A physiological increase in the hepatic glycogen level does not affect the response of net hepatic glucose uptake to insulin. Am J Physiol Endocrinol Metab 297:E358-66

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