Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK044083-05
Application #
2143506
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Project Start
1991-09-15
Project End
1999-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Cornell University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
City
Ithaca
State
NY
Country
United States
Zip Code
14850
Bhandari, Dhananjay M; Fedoseyenko, Dmytro; Begley, Tadhg P (2018) Mechanistic Studies on Tryptophan Lyase (NosL): Identification of Cyanide as a Reaction Product. J Am Chem Soc 140:542-545
Adak, Sanjoy; Begley, Tadhg P (2017) Flavin-N5-oxide: A new, catalytic motif in flavoenzymology. Arch Biochem Biophys 632:4-10
Wang, Yuanyou; Schnell, Bastien; Baumann, Sascha et al. (2017) Biosynthesis of Branched Alkoxy Groups: Iterative Methyl Group Alkylation by a Cobalamin-Dependent Radical SAM Enzyme. J Am Chem Soc 139:1742-1745
Adak, Sanjoy; Begley, Tadhg P (2017) RutA-Catalyzed Oxidative Cleavage of the Uracil Amide Involves Formation of a Flavin-N5-oxide. Biochemistry 56:3708-3709
Rodrigues, Matthew J; Windeisen, Volker; Zhang, Yang et al. (2017) Lysine relay mechanism coordinates intermediate transfer in vitamin B6 biosynthesis. Nat Chem Biol 13:290-294
Eser, Bekir E; Zhang, Xuan; Chanani, Prem K et al. (2016) From Suicide Enzyme to Catalyst: The Iron-Dependent Sulfide Transfer in Methanococcus jannaschii Thiamin Thiazole Biosynthesis. J Am Chem Soc 138:3639-42
Xu, Hui; Chakrabarty, Yindrila; Philmus, Benjamin et al. (2016) Identification of the First Riboflavin Catabolic Gene Cluster Isolated from Microbacterium maritypicum G10. J Biol Chem 291:23506-23515
Nemeria, Natalia S; Shome, Brateen; DeColli, Alicia A et al. (2016) Competence of Thiamin Diphosphate-Dependent Enzymes with 2'-Methoxythiamin Diphosphate Derived from Bacimethrin, a Naturally Occurring Thiamin Anti-vitamin. Biochemistry 55:1135-48
Jhulki, Isita; Chanani, Prem K; Abdelwahed, Sameh H et al. (2016) A Remarkable Oxidative Cascade That Replaces the Riboflavin C8 Methyl with an Amino Group during Roseoflavin Biosynthesis. J Am Chem Soc 138:8324-7
Zhang, Xuan; Eser, Bekir E; Chanani, Prem K et al. (2016) Structural Basis for Iron-Mediated Sulfur Transfer in Archael and Yeast Thiazole Synthases. Biochemistry 55:1826-38

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