Structure and Function of Retinoic Acid Receptors

Soprano, Dianne R.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: Research Project (R01)
• Project #: 2R01DK044517-04A1
• Application #: 2143859
• Study Section: Special Emphasis Panel (ZRG2-PSF (01))
• Project Start: 1992-09-30
• Project End: 2000-08-31
• Budget Start: 1996-09-01
• Budget End: 1997-08-31
• Support Year: 4
• Fiscal Year: 1996

Institution

• Name: Temple University
• Department: Biochemistry
• Type: Schools of Medicine
• City: Philadelphia
• State: PA
• Country: United States
• Zip Code: 19122

Publications

Zhao, Jianhua; Zhang, Zhenping; Vucetic, Zivjena et al. (2009) HACE1: A novel repressor of RAR transcriptional activity. J Cell Biochem 107:482-93

Vucetic, Zivjena; Zhang, Zhenping; Zhao, Jianhua et al. (2008) Acinus-S'represses retinoic acid receptor (RAR)-regulated gene expression through interaction with the B domains of RARs. Mol Cell Biol 28:2549-58

Qin, Pu; Haberbusch, Juliet M; Zhang, Zhenping et al. (2004) Pre-B cell leukemia transcription factor (PBX) proteins are important mediators for retinoic acid-dependent endodermal and neuronal differentiation of mouse embryonal carcinoma P19 cells. J Biol Chem 279:16263-71

Qin, Pu; Haberbusch, Juliet M; Soprano, Kenneth J et al. (2004) Retinoic acid regulates the expression of PBX1, PBX2, and PBX3 in P19 cells both transcriptionally and post-translationally. J Cell Biochem 92:147-63

Soprano, Dianne Robert; Qin, Pu; Soprano, Kenneth J (2004) Retinoic acid receptors and cancers. Annu Rev Nutr 24:201-21

Zhang, Zeng Ping; Hutcheson, Juliet M; Poynton, Helen C et al. (2003) Arginine of retinoic acid receptor beta which coordinates with the carboxyl group of retinoic acid functions independent of the amino acid residues responsible for retinoic acid receptor subtype ligand specificity. Arch Biochem Biophys 409:375-84

Soprano, D R; Scanlon, E; Shukri, M et al. (2000) Murine RARbeta4 displays reduced transactivation activity, lower affinity for retinoic acid, and no anti-AP1 activity. J Cell Biochem 77:604-14

Zhang, Z P; Shukri, M; Gambone, C J et al. (2000) Role of Ser(289) in RARgamma and its homologous amino acid residue of RARalpha and RARbeta in the binding of retinoic acid. Arch Biochem Biophys 380:339-46

Zhang, Z P; Gambone, C J; Gabriel, J L et al. (1998) Arg278, but not Lys229 or Lys236, plays an important role in the binding of retinoic acid by retinoic acid receptor gamma. J Biol Chem 273:34016-21

Wolfgang, C L; Zhang, Z; Gabriel, J L et al. (1997) Identification of sulfhydryl-modified cysteine residues in the ligand binding pocket of retinoic acid receptor beta. J Biol Chem 272:746-53