Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
3R01DK044923-05S1
Application #
2144181
Study Section
Biochemical Endocrinology Study Section (BCE)
Project Start
1996-02-23
Project End
1996-06-30
Budget Start
1996-02-23
Budget End
1996-06-30
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Nebraska Medical Center
Department
Pharmacology
Type
Schools of Medicine
DUNS #
City
Omaha
State
NE
Country
United States
Zip Code
68198
Carrigan, Patricia E; Sikkink, Laura A; Smith, David F et al. (2006) Domain:domain interactions within Hop, the Hsp70/Hsp90 organizing protein, are required for protein stability and structure. Protein Sci 15:522-32
Bredemeyer, Andrew J; Carrigan, Patricia E; Fehniger, Todd A et al. (2006) Hop cleavage and function in granzyme B-induced apoptosis. J Biol Chem 281:37130-41
Carrigan, Patricia E; Riggs, Daniel L; Chinkers, Michael et al. (2005) Functional comparison of human and Drosophila Hop reveals novel role in steroid receptor maturation. J Biol Chem 280:8906-11
Riggs, Daniel L; Cox, Marc B; Cheung-Flynn, Joyce et al. (2004) Functional specificity of co-chaperone interactions with Hsp90 client proteins. Crit Rev Biochem Mol Biol 39:279-95
Carrigan, Patricia E; Nelson, Gregory M; Roberts, Patricia J et al. (2004) Multiple domains of the co-chaperone Hop are important for Hsp70 binding. J Biol Chem 279:16185-93
Nelson, Gregory M; Prapapanich, Viravan; Carrigan, Patricia E et al. (2004) The heat shock protein 70 cochaperone hip enhances functional maturation of glucocorticoid receptor. Mol Endocrinol 18:1620-30
Smith, David F (2004) Tetratricopeptide repeat cochaperones in steroid receptor complexes. Cell Stress Chaperones 9:109-21
Nelson, Gregory M; Huffman, Holly; Smith, David F (2003) Comparison of the carboxy-terminal DP-repeat region in the co-chaperones Hop and Hip. Cell Stress Chaperones 8:125-33
Riggs, Daniel L; Roberts, Patricia J; Chirillo, Samantha C et al. (2003) The Hsp90-binding peptidylprolyl isomerase FKBP52 potentiates glucocorticoid signaling in vivo. EMBO J 22:1158-67
Cheung, J; Smith, D F (2000) Molecular chaperone interactions with steroid receptors: an update. Mol Endocrinol 14:939-46

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