Abstract

This is an application for continuing support for a program focused on the regulatory mechanisms of enterostatin. The peptide enterostatin is a product of a prepeptide called procolipase, which was originally identified in the gut in connection with fat absorption. The previous support for this project has allowed progress in which the investigator has provided evidence for both peripheral and central sites of action for enterostatin. The presumption currently is that the central enterostatin action sites are separate and may be responding to a separate source of enterostatin. Given the current state of knowledge in this area the investigator identifies the following aims for this proposal. First they seek to identify the enterostatin receptor by an expression cloning technique. Second they will characterize the enterostatin receptor and its regulation by dietary fat and by hormones. Third they will investigate how signaling pathways activated by fatty acids in the mouth or gut interact with enterostatin responsive pathways to regulate fat intake. Fourth they will identify the neuropathways responsive to enterostatin by immunohistochemistry and tract tracing techniques. Finally these pathway responsiveness to dietary fat will be evaluated.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
7R01DK045278-14
Application #
7327471
Study Section
Special Emphasis Panel (ZRG1-REN (02))
Program Officer
Yanovski, Susan Z
Project Start
1992-09-30
Project End
2007-09-30
Budget Start
2006-07-01
Budget End
2007-09-30
Support Year
14
Fiscal Year
2005
Total Cost
$79,172
Indirect Cost

  Institution

Name
Utah State University
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
072983455
City
Logan
State
UT
Country
United States
Zip Code
84322

  Publications

Ilnytska, Olha; Stütz, Adrian M; Park-York, MieJung et al. (2011) Molecular mechanisms for activation of the agouti-related protein and stimulation of appetite. Diabetes 60:97-106
Park, Miejung; Farrell, Jeffery; Lemmon, Karalee et al. (2009) Enterostatin alters protein trafficking to inhibit insulin secretion in Beta-TC6 cells. Peptides 30:1866-73
Park, Miejung; Oh, Hyoungil; York, David A (2009) Enterostatin affects cyclic AMP and ERK signaling pathways to regulate Agouti-related protein (AgRP) expression. Peptides 30:181-90
Park, M; Lyons 3rd, J; Oh, H et al. (2008) Enterostatin inhibition of angiogenesis: possible role of pAMPK and vascular endothelial growth factor A (VEGF-A). Int J Obes (Lond) 32:922-9
Lin, Ling; Park, Miejung; York, David A (2007) Enterostatin inhibition of dietary fat intake is modulated through the melanocortin system. Peptides 28:643-9
York, David A; Lin, Ling; Thomas, Sonjya R et al. (2006) Procolipase gene expression in the rat brain: source of endogenous enterostatin production in the brain. Brain Res 1087:52-9
Yang, Jichun; Wong, Ryan K; Park, MieJung et al. (2006) Leucine regulation of glucokinase and ATP synthase sensitizes glucose-induced insulin secretion in pancreatic beta-cells. Diabetes 55:193-201
Lin, Ling; Park, Miejung; Hulver, Matt et al. (2006) Different metabolic responses to central and peripheral injection of enterostatin. Am J Physiol Regul Integr Comp Physiol 290:R909-15
Lin, Ling; York, David A (2005) 5-HT1B receptors modulate the feeding inhibitory effects of enterostatin. Brain Res 1062:26-31
Lin, Ling; York, David A (2004) Amygdala enterostatin induces c-Fos expression in regions of hypothalamus that innervate the PVN. Brain Res 1020:147-53

Showing the most recent 10 out of 33 publications