Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK045773-04
Application #
2145015
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Project Start
1993-01-01
Project End
1997-12-31
Budget Start
1996-02-27
Budget End
1996-12-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Colorado Denver
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
065391526
City
Aurora
State
CO
Country
United States
Zip Code
80045
Plenter, Robert J; Grazia, Todd J; Coulombe, Marilyne G et al. (2018) Anti-LFA-1 induces CD8 T-cell dependent allograft tolerance and augments suppressor phenotype CD8 cells. Cell Immunol 332:101-110
Plenter, Robert J; Grazia, Todd J; Nelson, David P et al. (2015) Ectopic expression of Fas Ligand on cardiomyocytes renders cardiac allografts resistant to CD4(+) T-cell mediated rejection. Cell Immunol 293:30-3
Plenter, Robert J; Grazia, Todd J; Doan, An N et al. (2012) CD4 T cells mediate cardiac xenograft rejection via host MHC Class II. J Heart Lung Transplant 31:1018-24
Rayat, Gina R; Gill, Ronald G (2005) Indefinite survival of neonatal porcine islet xenografts by simultaneous targeting of LFA-1 and CD154 or CD45RB. Diabetes 54:443-51
Johnson, Z; Beilke, J; Pietra, B et al. (2004) Distinct requirements for host CD80/CD86 costimulatory molecules in cardiac versus islet rejection. Transplant Proc 36:1171-2
Rayat, Gina R; Johnson, Zachary A; Beilke, Joshua N et al. (2003) The degree of phylogenetic disparity of islet grafts dictates the reliance on indirect CD4 T-cell antigen recognition for rejection. Diabetes 52:1433-40
Rayat, Gina R; Gill, Ronald G (2003) Pancreatic islet xenotransplantation: barriers and prospects. Curr Diab Rep 3:336-43
Coulombe, M; Gill, R G (1996) T lymphocyte indifference to extrathymic islet allografts. J Immunol 156:1998-2003
Gill, R G; Wolf, L (1995) Immunobiology of cellular transplantation. Cell Transplant 4:361-70
Wolf, L A; Coulombe, M; Gill, R G (1995) Donor antigen-presenting cell-independent rejection of islet xenografts. Transplantation 60:1164-70

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