Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK045881-05
Application #
2016605
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Project Start
1992-09-30
Project End
1998-09-29
Budget Start
1996-09-30
Budget End
1998-09-29
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Dartmouth College
Department
Physiology
Type
Schools of Medicine
DUNS #
041027822
City
Hanover
State
NH
Country
United States
Zip Code
03755
Stanton, Bruce A; Coutermarsh, Bonita; Barnaby, Roxanna et al. (2015) Pseudomonas aeruginosa Reduces VX-809 Stimulated F508del-CFTR Chloride Secretion by Airway Epithelial Cells. PLoS One 10:e0127742
Koeppen, Katja; Coutermarsh, Bonita A; Madden, Dean R et al. (2014) Serum- and glucocorticoid-induced protein kinase 1 (SGK1) increases the cystic fibrosis transmembrane conductance regulator (CFTR) in airway epithelial cells by phosphorylating Shank2E protein. J Biol Chem 289:17142-50
Bomberger, Jennifer M; Ely, Kenneth H; Bangia, Naveen et al. (2014) Pseudomonas aeruginosa Cif protein enhances the ubiquitination and proteasomal degradation of the transporter associated with antigen processing (TAP) and reduces major histocompatibility complex (MHC) class I antigen presentation. J Biol Chem 289:152-62
Hampton, Thomas H; Ballok, Alicia E; Bomberger, Jennifer M et al. (2012) Does the F508-CFTR mutation induce a proinflammatory response in human airway epithelial cells? Am J Physiol Lung Cell Mol Physiol 303:L509-18
Bomberger, Jennifer M; Ye, Siying; Maceachran, Daniel P et al. (2011) A Pseudomonas aeruginosa toxin that hijacks the host ubiquitin proteolytic system. PLoS Pathog 7:e1001325
Hampton, Thomas H; Stanton, Bruce A (2010) A novel approach to analyze gene expression data demonstrates that the DeltaF508 mutation in CFTR downregulates the antigen presentation pathway. Am J Physiol Lung Cell Mol Physiol 298:L473-82
Ye, Siying; Cihil, Kristine; Stolz, Donna Beer et al. (2010) c-Cbl facilitates endocytosis and lysosomal degradation of cystic fibrosis transmembrane conductance regulator in human airway epithelial cells. J Biol Chem 285:27008-18
Bomberger, Jennifer M; Maceachran, Daniel P; Coutermarsh, Bonita A et al. (2009) Long-distance delivery of bacterial virulence factors by Pseudomonas aeruginosa outer membrane vesicles. PLoS Pathog 5:e1000382
Talebian, Laleh; Coutermarsh, Bonita; Channon, Jacqueline Y et al. (2009) Corr4A and VRT325 do not reduce the inflammatory response to P. aeruginosa in human cystic fibrosis airway epithelial cells. Cell Physiol Biochem 23:199-204
Ye, Siying; MacEachran, Daniel P; Hamilton, Joshua W et al. (2008) Chemotoxicity of doxorubicin and surface expression of P-glycoprotein (MDR1) is regulated by the Pseudomonas aeruginosa toxin Cif. Am J Physiol Cell Physiol 295:C807-18

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