Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK045960-05
Application #
2016612
Study Section
Immunological Sciences Study Section (IMS)
Project Start
1992-09-30
Project End
1997-12-31
Budget Start
1996-09-30
Budget End
1997-12-31
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Wayne State University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
City
Detroit
State
MI
Country
United States
Zip Code
48202

  Publications

Kong, Yi-chi M; Brown, Nicholas K; Flynn, Jeffrey C et al. (2011) Efficacy of HLA-DRB1ýýý03:01 and H2E transgenic mouse strains to correlate pathogenic thyroglobulin epitopes for autoimmune thyroiditis. J Autoimmun 37:63-70
Kong, Yi-chi M; Wei, Wei-Zen; Tomer, Yaron (2010) Opportunistic autoimmune disorders: from immunotherapy to immune dysregulation. Ann N Y Acad Sci 1183:222-36
Morris, Gerald P; Brown, Nicholas K; Kong, Yi-chi M (2009) Naturally-existing CD4(+)CD25(+)Foxp3(+) regulatory T cells are required for tolerance to experimental autoimmune thyroiditis induced by either exogenous or endogenous autoantigen. J Autoimmun 33:68-76
Kong, Yi-chi M; Jacob, Jennifer B; Flynn, Jeffrey C et al. (2009) Autoimmune thyroiditis as an indicator of autoimmune sequelae during cancer immunotherapy. Autoimmun Rev 9:28-33
Kong, Yi-Chi M; Morris, Gerald P; Brown, Nicholas K et al. (2009) Autoimmune thyroiditis: a model uniquely suited to probe regulatory T cell function. J Autoimmun 33:239-46
Jacob, Jennifer B; Kong, Yi-chi M; Nalbantoglu, Ilke et al. (2009) Tumor regression following DNA vaccination and regulatory T cell depletion in neu transgenic mice leads to an increased risk for autoimmunity. J Immunol 182:5873-81
Brown, Nicholas K; McCormick, Daniel J; David, Chella S et al. (2008) H2E-derived Ealpha52-68 peptide presented by H2Ab interferes with clonal deletion of autoreactive T cells in autoimmune thyroiditis. J Immunol 180:7039-46
Brown, Nicholas K; McCormick, Daniel J; Brusic, Vladimir et al. (2008) A novel H2A-E+ transgenic model susceptible to human but not mouse thyroglobulin-induced autoimmune thyroiditis: identification of mouse pathogenic epitopes. Cell Immunol 251:1-7
Flynn, Jeffrey C; Gilbert, Jacqueline A; Meroueh, Chady et al. (2007) Chronic exposure in vivo to thyrotropin receptor stimulating monoclonal antibodies sustains high thyroxine levels and thyroid hyperplasia in thyroid autoimmunity-prone HLA-DRB1*0301 transgenic mice. Immunology 122:261-7
Kong, Yi-Chi M; Flynn, Jeffrey C; Banga, J Paul et al. (2007) Application of HLA class II transgenic mice to study autoimmune regulation. Thyroid 17:995-1003

Showing the most recent 10 out of 45 publications