Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK046577-02
Application #
2145807
Study Section
General Medicine A Subcommittee 2 (GMA)
Project Start
1995-02-01
Project End
2000-01-31
Budget Start
1996-04-20
Budget End
1997-01-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
City
Rochester
State
MN
Country
United States
Zip Code
55905
Harikumar, Kaleeckal G; Augustine, Mary Lou; Lee, Leo T O et al. (2016) Structure and Function of Cross-class Complexes of G Protein-coupled Secretin and Angiotensin 1a Receptors. J Biol Chem 291:17332-44
Dong, Maoqing; Lam, Polo C-H; Orry, Andrew et al. (2016) Use of Cysteine Trapping to Map Spatial Approximations between Residues Contributing to the Helix N-capping Motif of Secretin and Distinct Residues within Each of the Extracellular Loops of Its Receptor. J Biol Chem 291:5172-84
Lee, Leo T O; Ng, Stephanie Y L; Chu, Jessica Y S et al. (2014) Transmembrane peptides as unique tools to demonstrate the in vivo action of a cross-class GPCR heterocomplex. FASEB J 28:2632-44
Dong, M; Koole, C; Wootten, D et al. (2014) Structural and functional insights into the juxtamembranous amino-terminal tail and extracellular loop regions of class B GPCRs. Br J Pharmacol 171:1085-101
Miller, Laurence J; Dong, Maoqing (2013) The orthosteric agonist-binding pocket in the prototypic class B G-protein-coupled secretin receptor. Biochem Soc Trans 41:154-8
Koole, Cassandra; Savage, Emilia E; Christopoulos, Arthur et al. (2013) Minireview: Signal bias, allosterism, and polymorphic variation at the GLP-1R: implications for drug discovery. Mol Endocrinol 27:1234-44
Miller, Laurence J (2013) Molecular basis of peptide activation of the GLP-1 receptor. Mol Metab 2:60-1
Dong, Maoqing; Pinon, Delia I; Miller, Laurence J (2013) Insights into the impact of phenolic residue incorporation at each position along secretin for receptor binding and biological activity. Regul Pept 180:5-11
Ke, Jiyuan; Harikumar, Kaleeckal G; Erice, Clara et al. (2013) Structure and function of Norrin in assembly and activation of a Frizzled 4-Lrp5/6 complex. Genes Dev 27:2305-19
Qi, T; Dong, M; Watkins, H A et al. (2013) Receptor activity-modifying protein-dependent impairment of calcitonin receptor splice variant ýý(1-47)hCT((a)) function. Br J Pharmacol 168:644-57

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