Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK046923-03
Application #
2146217
Study Section
General Medicine A Subcommittee 2 (GMA)
Project Start
1994-05-01
Project End
1998-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Kentucky
Department
Pharmacology
Type
Schools of Medicine
DUNS #
832127323
City
Lexington
State
KY
Country
United States
Zip Code
40506
Athippozhy, Antony; Huang, Liping; Wooton-Kee, Clavia Ruth et al. (2011) Differential gene expression in liver and small intestine from lactating rats compared to age-matched virgin controls detects increased mRNA of cholesterol biosynthetic genes. BMC Genomics 12:95
Wooton-Kee, Clavia Ruth; Coy, Donna J; Athippozhy, Antony T et al. (2010) Mechanisms for increased expression of cholesterol 7alpha-hydroxylase (Cyp7a1) in lactating rats. Hepatology 51:277-85
Wooton-Kee, Clavia Ruth; Cohen, David E; Vore, Mary (2008) Increased cholesterol 7alpha-hydroxylase expression and size of the bile acid pool in the lactating rat. Am J Physiol Gastrointest Liver Physiol 294:G1009-16
Wood, M; Ananthanarayanan, M; Jones, B et al. (2005) Hormonal regulation of hepatic organic anion transporting polypeptides. Mol Pharmacol 68:218-25
Cao, Jingsong; Wood, Marcie; Liu, Yong et al. (2004) Estradiol represses prolactin-induced expression of Na+/taurocholate cotransporting polypeptide in liver cells through estrogen receptor-alpha and signal transducers and activators of transcription 5a. Endocrinology 145:1739-49
Mottino, Aldo D; Hoffman, Tim; Dawson, Paul A et al. (2002) Increased expression of ileal apical sodium-dependent bile acid transporter in postpartum rats. Am J Physiol Gastrointest Liver Physiol 282:G41-50
Cao, J; Gowri, P M; Ganguly, T C et al. (2001) PRL, placental lactogen, and GH induce NA(+)/taurocholate-cotransporting polypeptide gene expression by activating signal transducer and activator of transcription-5 in liver cells. Endocrinology 142:4212-22
Cao, J; Huang, L; Liu, Y et al. (2001) Differential regulation of hepatic bile salt and organic anion transporters in pregnant and postpartum rats and the role of prolactin. Hepatology 33:140-7
Mottino, A D; Hoffman, T; Jennes, L et al. (2001) Expression of multidrug resistance-associated protein 2 in small intestine from pregnant and postpartum rats. Am J Physiol Gastrointest Liver Physiol 280:G1261-73
Ganguly, T C; O'Brien, M L; Karpen, S J et al. (1997) Regulation of the rat liver sodium-dependent bile acid cotransporter gene by prolactin. Mediation of transcriptional activation by Stat5. J Clin Invest 99:2906-14

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