Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK046971-03
Application #
2146292
Study Section
Metabolic Pathology Study Section (MEP)
Program Officer
Serrano, Jose
Project Start
1993-07-15
Project End
1998-06-30
Budget Start
1995-07-01
Budget End
1996-06-30
Support Year
3
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Patchornik, Guy; Munson, Keith; Goldshleger, Rivka et al. (2002) The ATP-Mg2+ binding site and cytoplasmic domain interactions of Na+,K+-ATPase investigated with Fe2+-catalyzed oxidative cleavage and molecular modeling. Biochemistry 41:11740-9
Buck, M; Kim, D J; Houglum, K et al. (2000) c-Myb modulates transcription of the alpha-smooth muscle actin gene in activated hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol 278:G321-8
Houglum, K; Buck, M; Kim, D J et al. (1998) TNF-alpha inhibits liver collagen-alpha 1(I) gene expression through a tissue-specific regulatory region. Am J Physiol 274:G840-7
Chojkier, M; Houglum, K; Lee, K S et al. (1998) Long- and short-term D-alpha-tocopherol supplementation inhibits liver collagen alpha1(I) gene expression. Am J Physiol 275:G1480-5
Houglum, K; Venkataramani, A; Lyche, K et al. (1997) A pilot study of the effects of d-alpha-tocopherol on hepatic stellate cell activation in chronic hepatitis C. Gastroenterology 113:1069-73
Lee, K S; Cottam, H B; Houglum, K et al. (1997) Pentoxifylline blocks hepatic stellate cell activation independently of phosphodiesterase inhibitory activity. Am J Physiol 273:G1094-100
Houglum, K; Ramm, G A; Crawford, D H et al. (1997) Excess iron induces hepatic oxidative stress and transforming growth factor beta1 in genetic hemochromatosis. Hepatology 26:605-10
Houglum, K; Lee, K S; Chojkier, M (1997) Proliferation of hepatic stellate cells is inhibited by phosphorylation of CREB on serine 133. J Clin Invest 99:1322-8
Buck, M; Chojkier, M (1996) Muscle wasting and dedifferentiation induced by oxidative stress in a murine model of cachexia is prevented by inhibitors of nitric oxide synthesis and antioxidants. EMBO J 15:1753-65
Lee, K S; Buck, M; Houglum, K et al. (1995) Activation of hepatic stellate cells by TGF alpha and collagen type I is mediated by oxidative stress through c-myb expression. J Clin Invest 96:2461-8

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