Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK047318-02
Application #
2016732
Study Section
General Medicine A Subcommittee 2 (GMA)
Project Start
1995-09-30
Project End
1998-08-31
Budget Start
1996-09-23
Budget End
1997-08-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Cincinnati Children's Hospital Medical Center
Department
Type
DUNS #
071284913
City
Cincinnati
State
OH
Country
United States
Zip Code
45229
Amarachintha, Surya; Harmel-Laws, Eleana; Steinbrecher, Kris A (2018) Guanylate cyclase C reduces invasion of intestinal epithelial cells by bacterial pathogens. Sci Rep 8:1521
Steinbrecher, Kris A (2014) The multiple roles of guanylate cyclase C, a heat stable enterotoxin receptor. Curr Opin Gastroenterol 30:1-6
Harmel-Laws, Eleana; Mann, Elizabeth A; Cohen, Mitchell B et al. (2013) Guanylate cyclase C deficiency causes severe inflammation in a murine model of spontaneous colitis. PLoS One 8:e79180
Mann, Elizabeth A; Harmel-Laws, Eleana; Cohen, Mitchell B et al. (2013) Guanylate cyclase C limits systemic dissemination of a murine enteric pathogen. BMC Gastroenterol 13:135
Steinbrecher, Kris A; Cohen, Mitchell B (2011) Transmembrane guanylate cyclase in intestinal pathophysiology. Curr Opin Gastroenterol 27:139-45
Han, Xiaonan; Mann, Elizabeth; Gilbert, Shila et al. (2011) Loss of guanylyl cyclase C (GCC) signaling leads to dysfunctional intestinal barrier. PLoS One 6:e16139
Steinbrecher, Kris A; Harmel-Laws, Eleana; Garin-Laflam, Monica P et al. (2011) Murine guanylate cyclase C regulates colonic injury and inflammation. J Immunol 186:7205-14
Mann, Elizabeth A; Shanmukhappa, Kumar; Cohen, Mitchell B (2010) Lack of guanylate cyclase C results in increased mortality in mice following liver injury. BMC Gastroenterol 10:86
Garin-Laflam, M P; Steinbrecher, K A; Rudolph, J A et al. (2009) Activation of guanylate cyclase C signaling pathway protects intestinal epithelial cells from acute radiation-induced apoptosis. Am J Physiol Gastrointest Liver Physiol 296:G740-9
Sellers, Zachary M; Mann, Elizabeth; Smith, Anders et al. (2008) Heat-stable enterotoxin of Escherichia coli (STa) can stimulate duodenal HCO3(-) secretion via a novel GC-C- and CFTR-independent pathway. FASEB J 22:1306-16

Showing the most recent 10 out of 26 publications