Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK047361-04
Application #
2146907
Study Section
General Medicine A Subcommittee 2 (GMA)
Project Start
1993-05-01
Project End
1998-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Magness, Scott T; Bataller, Ramon; Yang, Liu et al. (2004) A dual reporter gene transgenic mouse demonstrates heterogeneity in hepatic fibrogenic cell populations. Hepatology 40:1151-9
Magness, Scott T; Maeda, Nobuyo; Brenner, David A (2002) An exon 10 deletion in the mouse ferrochelatase gene has a dominant-negative effect and causes mild protoporphyria. Blood 100:1470-7
Magness, S T; Tugores, A; Brenner, D A (2000) Analysis of ferrochelatase expression during hematopoietic development of embryonic stem cells. Blood 95:3568-77
Solis-Herruzo, J A; Rippe, R A; Schrum, L W et al. (1999) Interleukin-6 increases rat metalloproteinase-13 gene expression through stimulation of activator protein 1 transcription factor in cultured fibroblasts. J Biol Chem 274:30919-26
Magness, S T; Brenner, D A (1999) Targeted disruption of the mouse ferrochelatase gene producing an exon 10 deletion. Biochim Biophys Acta 1453:161-74
Magness, S T; Tugores, A; Diala, E S et al. (1998) Analysis of the human ferrochelatase promoter in transgenic mice. Blood 92:320-8
Bloomer, J; Bruzzone, C; Zhu, L et al. (1998) Molecular defects in ferrochelatase in patients with protoporphyria requiring liver transplantation. J Clin Invest 102:107-14
Magness, S T; Brenner, D A (1995) Ferrochelatase cDNA delivered by adenoviral vector corrects biochemical defect in protoporphyric cells. Hum Gene Ther 6:1285-90
Magness, S T; Tugores, A; Christensen, S R et al. (1994) Deletion of the ferrochelatase gene in a patient with protoporphyria. Hum Mol Genet 3:1695-7
Tugores, A; Brenner, D A (1994) A method for in vitro DNase I footprinting analysis on supercoiled templates. Biotechniques 17:410-2