Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK047424-02
Application #
2147023
Study Section
Pathology A Study Section (PTHA)
Project Start
1995-01-01
Project End
1998-12-31
Budget Start
1996-01-25
Budget End
1996-12-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Clark, Amy G; Buckley, Elizabeth S; Foster, Mary H (2018) Altered toll-like receptor responsiveness underlies a dominant heritable defect in B cell tolerance in autoimmune New Zealand Black mice. Eur J Immunol 48:492-497
Clark, Amy G; Fan, Qihua; Brady, Graham F et al. (2013) Regulation of basement membrane-reactive B cells in BXSB, (NZBxNZW)F1, NZB, and MRL/lpr lupus mice. Autoimmunity 46:188-204
Clark, Amy G; Weston, Melissa L; Foster, Mary H (2013) Lack of galectin-1 or galectin-3 alters B cell deletion and anergy in an autoantibody transgene model. Glycobiology 23:893-903
Clark, Amy G; Mackin, Katherine M; Foster, Mary H (2011) Genetic elimination of ?3(IV) collagen fails to rescue anti-collagen B cells. Immunol Lett 141:134-9
Zhang, Ying; Su, Susan C; Hecox, Douglas B et al. (2008) Central tolerance regulates B cells reactive with Goodpasture antigen alpha3(IV)NC1 collagen. J Immunol 181:6092-100
Clark, Amy G; Mackin, Katherine M; Foster, Mary H (2008) Tracking Differential Gene Expression in MRL/MpJ Versus C57BL/6 Anergic B Cells: Molecular Markers of Autoimmunity. Biomark Insights 3:335-350
Foster, Mary H (2007) T cells and B cells in lupus nephritis. Semin Nephrol 27:47-58
Clark, Amy G; Chen, Sihong; Zhang, Hao et al. (2007) Multifunctional regulators of cell growth are differentially expressed in anergic murine B cells. Mol Immunol 44:1274-85
Foster, Mary H; Zhang, Ying; Clark, Amy G (2006) Deconstructing B cell tolerance to basement membranes. Arch Immunol Ther Exp (Warsz) 54:227-37
Brady, Graham F; Congdon, Kendra L; Clark, Amy G et al. (2004) Kappa editing rescues autoreactive B cells destined for deletion in mice transgenic for a dual specific anti-laminin Ig. J Immunol 172:5313-21

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