Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
3R01DK047870-03S1
Application #
2651333
Study Section
Medical Biochemistry Study Section (MEDB)
Program Officer
Mckeon, Catherine T
Project Start
1995-08-01
Project End
1998-07-31
Budget Start
1997-08-01
Budget End
1998-07-31
Support Year
3
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Pediatrics
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Shi, Dashuang; Allewell, Norma M; Tuchman, Mendel (2015) From Genome to Structure and Back Again: A Family Portrait of the Transcarbamylases. Int J Mol Sci 16:18836-64
Ah Mew, Nicholas; McCarter, Robert; Daikhin, Yevgeny et al. (2014) Augmenting ureagenesis in patients with partial carbamyl phosphate synthetase 1 deficiency with N-carbamyl-L-glutamate. J Pediatr 165:401-403.e3
Shi, Dashuang; Yu, Xiaolin; Zhao, Gengxiang et al. (2012) Crystal structure and biochemical properties of putrescine carbamoyltransferase from Enterococcus faecalis: Assembly, active site, and allosteric regulation. Proteins 80:1436-47
Nissim, Itzhak; Horyn, Oksana; Nissim, Ilana et al. (2011) Down-regulation of hepatic urea synthesis by oxypurines: xanthine and uric acid inhibit N-acetylglutamate synthase. J Biol Chem 286:22055-68
Li, Yongdong; Jin, Zhongmin; Yu, Xiaolin et al. (2011) The ygeW encoded protein from Escherichia coli is a knotted ancestral catabolic transcarbamylase. Proteins 79:2327-34
Yudkoff, Marc; Ah Mew, Nicholas; Daikhin, Yevgeny et al. (2010) Measuring in vivo ureagenesis with stable isotopes. Mol Genet Metab 100 Suppl 1:S37-41
Li, Yongdong; Yu, Xiaolin; Ho, Jeremy et al. (2010) Reversible post-translational carboxylation modulates the enzymatic activity of N-acetyl-L-ornithine transcarbamylase. Biochemistry 49:6887-95
Caldovic, Ljubica; Ah Mew, Nicholas; Shi, Dashuang et al. (2010) N-acetylglutamate synthase: structure, function and defects. Mol Genet Metab 100 Suppl 1:S13-9
Ah Mew, Nicholas; McCarter, Robert; Daikhin, Yevgeny et al. (2010) N-carbamylglutamate augments ureagenesis and reduces ammonia and glutamine in propionic acidemia. Pediatrics 126:e208-14
Ah Mew, Nicholas; Payan, Irma; Daikhin, Yevgeny et al. (2009) Effects of a single dose of N-carbamylglutamate on the rate of ureagenesis. Mol Genet Metab 98:325-30

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