Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
7R01DK047919-04
Application #
2387084
Study Section
Metabolism Study Section (MET)
Project Start
1994-05-01
Project End
1998-04-30
Budget Start
1996-11-21
Budget End
1997-04-30
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Texas Sw Medical Center Dallas
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Dallas
State
TX
Country
United States
Zip Code
75390
Uchizono, Y; Alarcon, C; Wicksteed, B L et al. (2007) The balance between proinsulin biosynthesis and insulin secretion: where can imbalance lead? Diabetes Obes Metab 9 Suppl 2:56-66
Marsh, Brad J; Soden, Chad; Alarcon, Cristina et al. (2007) Regulated autophagy controls hormone content in secretory-deficient pancreatic endocrine beta-cells. Mol Endocrinol 21:2255-69
Hays, L B; Wicksteed, B; Wang, Y et al. (2005) Intragranular targeting of syncollin, but not a syncollinGFP chimera, inhibits regulated insulin exocytosis in pancreatic beta-cells. J Endocrinol 185:57-67
Wasle, Barbara; Hays, Lori B; Rhodes, Christopher J et al. (2004) Syncollin inhibits regulated corticotropin secretion from AtT-20 cells through a reduction in the secretory vesicle population. Biochem J 380:897-905
Michael, Darren J; Geng, Xuehui; Cawley, Niamh X et al. (2004) Fluorescent cargo proteins in pancreatic beta-cells: design determines secretion kinetics at exocytosis. Biophys J 87:L03-5
Wicksteed, Barton; Alarcon, Cristina; Briaud, Isabelle et al. (2003) Glucose-induced translational control of proinsulin biosynthesis is proportional to preproinsulin mRNA levels in islet beta-cells but not regulated via a positive feedback of secreted insulin. J Biol Chem 278:42080-90
Yaekura, Kazuro; Julyan, Richard; Wicksteed, Barton L et al. (2003) Insulin secretory deficiency and glucose intolerance in Rab3A null mice. J Biol Chem 278:9715-21
Alarcon, Cristina; Wicksteed, Barton; Prentki, Marc et al. (2002) Succinate is a preferential metabolic stimulus-coupling signal for glucose-induced proinsulin biosynthesis translation. Diabetes 51:2496-504
Donelan, Matthew J; Morfini, Gerardo; Julyan, Richard et al. (2002) Ca2+-dependent dephosphorylation of kinesin heavy chain on beta-granules in pancreatic beta-cells. Implications for regulated beta-granule transport and insulin exocytosis. J Biol Chem 277:24232-42
Skelly, R H; Wicksteed, B; Antinozzi, P A et al. (2001) Glycerol-stimulated proinsulin biosynthesis in isolated pancreatic rat islets via adenoviral-induced expression of glycerol kinase is mediated via mitochondrial metabolism. Diabetes 50:1791-8

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