Abstract

GI peptides are ubiquitous substances, many of which are trophic for epithelial cell growth and development. These peptides modulate their effects after binding to specific receptors. Although there is some cross reactivity, the emergence and characterizations of unique receptors may provide better understanding into control of cellular proliferation. This proposal serves to characterize a unique gastrin associated receptor, G/G-Gly R, which appears to be distinct from the CCK-B receptor in its specificity and action. Better understanding of this receptor and its location, as well as mechanisms for cellular proliferation may allow the use of novel non-toxic forms of anti-neoplastic therapy in GI tract cancers.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK048345-07
Application #
6177366
Study Section
Surgery and Bioengineering Study Section (SB)
Program Officer
May, Michael K
Project Start
1994-08-01
Project End
2003-07-31
Budget Start
2000-08-01
Budget End
2001-07-31
Support Year
7
Fiscal Year
2000
Total Cost
$395,301
Indirect Cost

  Institution

Name
University of Texas Medical Br Galveston
Department
Surgery
Type
Schools of Medicine
DUNS #
041367053
City
Galveston
State
TX
Country
United States
Zip Code
77555

  Publications

Wen, Xiaodong; Chao, Celia; Ives, Kirk et al. (2011) Regulation of bombesin-stimulated cyclooxygenase-2 expression in prostate cancer cells. BMC Mol Biol 12:29
Chao, Celia; Han, Xueliang; Ives, Kirk et al. (2010) CCK2 receptor expression transforms non-tumorigenic human NCM356 colonic epithelial cells into tumor forming cells. Int J Cancer 126:864-75
Chao, Celia; Hellmich, Mark R (2010) Gastrin, inflammation, and carcinogenesis. Curr Opin Endocrinol Diabetes Obes 17:33-9
Chao, Celia; Ives, Kirk; Hellmich, Helen L et al. (2009) Gastrin-releasing peptide receptor in breast cancer mediates cellular migration and interleukin-8 expression. J Surg Res 156:26-31
Guo, Yan-Shi; Chen, Zihong; Wen, Xiao-Dong et al. (2008) Synergistic regulation of COX-2 expression by bombesin and transforming growth factor-beta. Dig Dis Sci 53:2045-52
Chao, C; Goluszko, E; Lee, Y-T et al. (2007) Constitutively active CCK2 receptor splice variant increases Src-dependent HIF-1 alpha expression and tumor growth. Oncogene 26:1013-9
Chao, Celia; Tallman, Marsha L; Ives, Kirk L et al. (2005) Gastrointestinal hormone receptors in primary human colorectal carcinomas. J Surg Res 129:313-21
Li, Nan; Wang, Qingding; Li, Jing et al. (2005) Inhibition of mitochondrial gene transcription suppresses neurotensin secretion in the human carcinoid cell line BON. Am J Physiol Gastrointest Liver Physiol 288:G213-20
Chao, Celia; Ives, Kirk L; Goluszko, Elizabeth et al. (2005) SRC regulates constitutive internalization and rapid resensitization of a cholecystokinin 2 receptor splice variant. J Biol Chem 280:33368-73
Olszewska-Pazdrak, Barbara; Townsend Jr, Courtney M; Hellmich, Mark R (2004) Agonist-independent activation of Src tyrosine kinase by a cholecystokinin-2 (CCK2) receptor splice variant. J Biol Chem 279:40400-4

Showing the most recent 10 out of 31 publications