Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK048494-02
Application #
2148830
Study Section
Metabolism Study Section (MET)
Project Start
1995-06-01
Project End
1998-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Chicago
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637
Liew, Chong Wee; Assmann, Anke; Templin, Andrew T et al. (2014) Insulin regulates carboxypeptidase E by modulating translation initiation scaffolding protein eIF4G1 in pancreatic ? cells. Proc Natl Acad Sci U S A 111:E2319-28
Fridlyand, Leonid E; Jacobson, David A; Philipson, L H (2013) Ion channels and regulation of insulin secretion in human ýý-cells: a computational systems analysis. Islets 5:1-15
Eames, Stefani C; Kinkel, Mary D; Rajan, Sindhu et al. (2013) Transgenic zebrafish model of the C43G human insulin gene mutation. J Diabetes Investig 4:157-67
Kaihara, Kelly A; Dickson, Lorna M; Jacobson, David A et al. (2013) ?-Cell-specific protein kinase A activation enhances the efficiency of glucose control by increasing acute-phase insulin secretion. Diabetes 62:1527-36
Fridlyand, Leonid E; Philipson, Louis H (2012) A computational systems analysis of factors regulating ýý cell glucagon secretion. Islets 4:262-83
Rajan, Sindhu; Torres, Jacqueline; Thompson, Michael S et al. (2012) SUMO downregulates GLP-1-stimulated cAMP generation and insulin secretion. Am J Physiol Endocrinol Metab 302:E714-23
Fridlyand, Leonid E; Philipson, Louis H (2011) Coupling of metabolic, second messenger pathways and insulin granule dynamics in pancreatic beta-cells: a computational analysis. Prog Biophys Mol Biol 107:293-303
Fridlyand, Leonid E; Phillipson, Louis H (2011) Mechanisms of glucose sensing in the pancreatic *-cell: A computational systems-based analysis. Islets 3:224-30
Eames, Stefani C; Philipson, Louis H; Prince, Victoria E et al. (2010) Blood sugar measurement in zebrafish reveals dynamics of glucose homeostasis. Zebrafish 7:205-13
Kinkel, Mary D; Eames, Stefani C; Philipson, Louis H et al. (2010) Intraperitoneal injection into adult zebrafish. J Vis Exp :

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