Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
2R01DK050376-05A2
Application #
6333161
Study Section
Metabolism Study Section (MET)
Program Officer
May, Michael K
Project Start
1995-09-01
Project End
2006-03-31
Budget Start
2001-06-01
Budget End
2002-03-31
Support Year
5
Fiscal Year
2001
Total Cost
$257,651
Indirect Cost
Name
University of Rochester
Department
Pathology
Type
Schools of Dentistry
DUNS #
208469486
City
Rochester
State
NY
Country
United States
Zip Code
14627
Chamberlain, Jeffrey M; O'Dell, Colleen; Sparks, Charles E et al. (2013) Insulin suppression of apolipoprotein B in McArdle RH7777 cells involves increased sortilin 1 interaction and lysosomal targeting. Biochem Biophys Res Commun 430:66-71
Sparks, Janet D; Chamberlain, Jeffrey M; O'Dell, Colleen et al. (2011) Acute suppression of apo B secretion by insulin occurs independently of MTP. Biochem Biophys Res Commun 406:252-6
Caviglia, Jorge M; Sparks, Janet D; Toraskar, Nikhil et al. (2009) ABHD5/CGI-58 facilitates the assembly and secretion of apolipoprotein B lipoproteins by McA RH7777 rat hepatoma cells. Biochim Biophys Acta 1791:198-205
Chirieac, Doru V; Davidson, Nicholas O; Sparks, Charles E et al. (2006) PI3-kinase activity modulates apo B available for hepatic VLDL production in apobec-1-/- mice. Am J Physiol Gastrointest Liver Physiol 291:G382-8
Nieman, Kristin M; Hartz, Cara S; Szegedi, Sandra S et al. (2006) Folate status modulates the induction of hepatic glycine N-methyltransferase and homocysteine metabolism in diabetic rats. Am J Physiol Endocrinol Metab 291:E1235-42
Chirieac, Doru V; Collins, Heidi L; Cianci, Joanne et al. (2004) Altered triglyceride-rich lipoprotein production in Zucker diabetic fatty rats. Am J Physiol Endocrinol Metab 287:E42-9
Au, Crystal S; Wagner, Amy; Chong, Taryne et al. (2004) Insulin regulates hepatic apolipoprotein B production independent of the mass or activity of Akt1/PKBalpha. Metabolism 53:228-35
Chirieac, Doru V; Cianci, Joanne; Collins, Heidi L et al. (2002) Insulin suppression of VLDL apo B secretion is not mediated by the LDL receptor. Biochem Biophys Res Commun 297:134-7
Fisher, E A; Pan, M; Chen, X et al. (2001) The triple threat to nascent apolipoprotein B. Evidence for multiple, distinct degradative pathways. J Biol Chem 276:27855-63
Sparks, J D; Shaw, W N; Corsetti, J P et al. (2000) Insulin-treated Zucker diabetic fatty rats retain the hypertriglyceridemia associated with obesity. Metabolism 49:1424-30

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