Insulin regulated hepatic apo B lipoprotein biogenesis

Sparks, Janet Dehoff

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: Research Project (R01)
• Project #: 5R01DK050376-08
• Application #: 6724843
• Study Section: Metabolism Study Section (MET)
• Program Officer: May, Michael K
• Project Start: 1995-09-01
• Project End: 2006-02-28
• Budget Start: 2004-03-01
• Budget End: 2005-02-28
• Support Year: 8
• Fiscal Year: 2004
• Total Cost: $265,169

Institution

• Name: University of Rochester
• Department: Pathology
• Type: Schools of Dentistry
• DUNS #: 041294109
• City: Rochester
• State: NY
• Country: United States
• Zip Code: 14627

Publications

Chamberlain, Jeffrey M; O'Dell, Colleen; Sparks, Charles E et al. (2013) Insulin suppression of apolipoprotein B in McArdle RH7777 cells involves increased sortilin 1 interaction and lysosomal targeting. Biochem Biophys Res Commun 430:66-71

Sparks, Janet D; Chamberlain, Jeffrey M; O'Dell, Colleen et al. (2011) Acute suppression of apo B secretion by insulin occurs independently of MTP. Biochem Biophys Res Commun 406:252-6

Caviglia, Jorge M; Sparks, Janet D; Toraskar, Nikhil et al. (2009) ABHD5/CGI-58 facilitates the assembly and secretion of apolipoprotein B lipoproteins by McA RH7777 rat hepatoma cells. Biochim Biophys Acta 1791:198-205

Chirieac, Doru V; Davidson, Nicholas O; Sparks, Charles E et al. (2006) PI3-kinase activity modulates apo B available for hepatic VLDL production in apobec-1-/- mice. Am J Physiol Gastrointest Liver Physiol 291:G382-8

Nieman, Kristin M; Hartz, Cara S; Szegedi, Sandra S et al. (2006) Folate status modulates the induction of hepatic glycine N-methyltransferase and homocysteine metabolism in diabetic rats. Am J Physiol Endocrinol Metab 291:E1235-42

Chirieac, Doru V; Collins, Heidi L; Cianci, Joanne et al. (2004) Altered triglyceride-rich lipoprotein production in Zucker diabetic fatty rats. Am J Physiol Endocrinol Metab 287:E42-9

Au, Crystal S; Wagner, Amy; Chong, Taryne et al. (2004) Insulin regulates hepatic apolipoprotein B production independent of the mass or activity of Akt1/PKBalpha. Metabolism 53:228-35

Chirieac, Doru V; Cianci, Joanne; Collins, Heidi L et al. (2002) Insulin suppression of VLDL apo B secretion is not mediated by the LDL receptor. Biochem Biophys Res Commun 297:134-7

Fisher, E A; Pan, M; Chen, X et al. (2001) The triple threat to nascent apolipoprotein B. Evidence for multiple, distinct degradative pathways. J Biol Chem 276:27855-63

Sparks, J D; Shaw, W N; Corsetti, J P et al. (2000) Insulin-treated Zucker diabetic fatty rats retain the hypertriglyceridemia associated with obesity. Metabolism 49:1424-30