Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK050984-02
Application #
2017146
Study Section
Special Emphasis Panel (SRC (05))
Project Start
1995-09-30
Project End
2000-08-31
Budget Start
1996-09-23
Budget End
1997-08-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Rieder, Florian; Fiocchi, Claudio; Rogler, Gerhard (2017) Mechanisms, Management, and Treatment of Fibrosis in Patients With Inflammatory Bowel Diseases. Gastroenterology 152:340-350.e6
Soroosh, Artin; Albeiroti, Sami; West, Gail A et al. (2016) Crohn's Disease Fibroblasts Overproduce the Novel Protein KIAA1199 to Create Proinflammatory Hyaluronan Fragments. Cell Mol Gastroenterol Hepatol 2:358-368.e4
Sadler, Tammy; Bhasin, Jeffrey M; Xu, Yaomin et al. (2016) Genome-wide analysis of DNA methylation and gene expression defines molecular characteristics of Crohn's disease-associated fibrosis. Clin Epigenetics 8:30
Dixon, Laura J; Kabi, Amrita; Nickerson, Kourtney P et al. (2015) Combinatorial effects of diet and genetics on inflammatory bowel disease pathogenesis. Inflamm Bowel Dis 21:912-22
Yoo, Jun Hwan; Ho, Samantha; Tran, Deanna Hoang-Yen et al. (2015) Anti-fibrogenic effects of the anti-microbial peptide cathelicidin in murine colitis-associated fibrosis. Cell Mol Gastroenterol Hepatol 1:55-74.e1
Nickerson, Kourtney P; Chanin, Rachael; McDonald, Christine (2015) Deregulation of intestinal anti-microbial defense by the dietary additive, maltodextrin. Gut Microbes 6:78-83
Kurada, S; Alkhouri, N; Fiocchi, C et al. (2015) Review article: breath analysis in inflammatory bowel diseases. Aliment Pharmacol Ther 41:329-41
Scarpa, Melania; Kessler, Sean; Sadler, Tammy et al. (2015) The epithelial danger signal IL-1? is a potent activator of fibroblasts and reactivator of intestinal inflammation. Am J Pathol 185:1624-37
Schuster, Andrew T; Homer, Craig R; Kemp, Jacqueline R et al. (2015) Chromosome-associated protein D3 promotes bacterial clearance in human intestinal epithelial cells by repressing expression of amino acid transporters. Gastroenterology 148:1405-1416.e3
Bakirtzi, Kyriaki; West, Gail; Fiocchi, Claudio et al. (2014) The neurotensin-HIF-1?-VEGF? axis orchestrates hypoxia, colonic inflammation, and intestinal angiogenesis. Am J Pathol 184:3405-14

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