Abstract

This revised application seeks to study androgen-regulated genes in the rat prostate.
Aim 1 is to test the hypothesis that calreticulin down-regulation facilitates Ca++ ionophore-induced prostatic cell death.
Aim 2 is to continue and expand identification of androgen-responsive genes in the prostate.
Aim 3 is to characterize the spatial and temporal androgenic regulation of potentially important response genes.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
3R01DK051193-03S1
Application #
6158084
Study Section
Biochemical Endocrinology Study Section (BCE)
Program Officer
Mullins, Christopher V
Project Start
1996-12-18
Project End
2000-11-30
Budget Start
1998-12-20
Budget End
1999-11-30
Support Year
3
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Northwestern University at Chicago
Department
Urology
Type
Schools of Medicine
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611

  Publications

Xiao, W; Zhang, Q; Habermacher, G et al. (2008) U19/Eaf2 knockout causes lung adenocarcinoma, B-cell lymphoma, hepatocellular carcinoma and prostatic intraepithelial neoplasia. Oncogene 27:1536-44
Saporita, Anthony J; Ai, Junkui; Wang, Zhou (2007) The Hsp90 inhibitor, 17-AAG, prevents the ligand-independent nuclear localization of androgen receptor in refractory prostate cancer cells. Prostate 67:509-20
Oram, Shane W; Ai, Junkui; Pagani, Gina M et al. (2007) Expression and function of the human androgen-responsive gene ADI1 in prostate cancer. Neoplasia 9:643-51
Hahn, Junghyun; Xiao, Wuhan; Jiang, Feng et al. (2007) Apoptosis induction and growth suppression by U19/Eaf2 is mediated through its ELL-binding domain. Prostate 67:146-53
Oram, Shane; Cai, Xiaoyan; Haleem, Riffat et al. (2006) Regulation of calcium homeostasis by S100RVP, an androgen-regulated S100 protein in the rat ventral prostate. Prostate 66:768-78
Eggener, Scott E; Stern, Jeff A; Jain, Pankaj M et al. (2006) Enhancement of intermittent androgen ablation by ""off-cycle"" maintenance with finasteride in LNCaP prostate cancer xenograft model. Prostate 66:495-502
Xiao, Wuhan; Jiang, Feng; Wang, Zhou (2006) ELL binding regulates U19/Eaf2 intracellular localization, stability, and transactivation. Prostate 66:1-12
Jiang, Feng; Wang, Zhou (2004) Identification and characterization of PLZF as a prostatic androgen-responsive gene. Prostate 59:426-35
Oram, Shane; Jiang, Feng; Cai, Xiaoyan et al. (2004) Identification and characterization of an androgen-responsive gene encoding an aci-reductone dioxygenase-like protein in the rat prostate. Endocrinology 145:1933-42
Abasolo, Ibane; Wang, Zhou; Montuenga, Luis M et al. (2004) Adrenomedullin inhibits prostate cancer cell proliferation through a cAMP-independent autocrine mechanism. Biochem Biophys Res Commun 322:878-86

Showing the most recent 10 out of 23 publications