Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
1R01DK051315-01
Application #
2152410
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Project Start
1996-05-01
Project End
2000-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Spencer, Netanya Y; Yan, Ziying; Cong, Le et al. (2016) Definitive localization of intracellular proteins: Novel approach using CRISPR-Cas9 genome editing, with glucose 6-phosphate dehydrogenase as a model. Anal Biochem 494:55-67
Spencer, Netanya Y; Engelhardt, John F (2014) The basic biology of redoxosomes in cytokine-mediated signal transduction and implications for disease-specific therapies. Biochemistry 53:1551-64
Spencer, Netanya Y; Zhou, Weihong; Li, Qiang et al. (2013) Hepatocytes produce TNF-? following hypoxia-reoxygenation and liver ischemia-reperfusion in a NADPH oxidase- and c-Src-dependent manner. Am J Physiol Gastrointest Liver Physiol 305:G84-94
Hara, Yuji; Balci-Hayta, Burcu; Yoshida-Moriguchi, Takako et al. (2011) A dystroglycan mutation associated with limb-girdle muscular dystrophy. N Engl J Med 364:939-46
Spencer, Netanya Y; Yan, Ziying; Boudreau, Ryan L et al. (2011) Control of hepatic nuclear superoxide production by glucose 6-phosphate dehydrogenase and NADPH oxidase-4. J Biol Chem 286:8977-87
Li, Qiang; Spencer, Netanya Y; Pantazis, Nicholas J et al. (2011) Alsin and SOD1(G93A) proteins regulate endosomal reactive oxygen species production by glial cells and proinflammatory pathways responsible for neurotoxicity. J Biol Chem 286:40151-62
Carter, Barrie J; Anklesaria, Pervin; Choi, Stephanie et al. (2009) Redox modifier genes and pathways in amyotrophic lateral sclerosis. Antioxid Redox Signal 11:1569-86
Li, Qiang; Spencer, Netanya Y; Oakley, Fredrick D et al. (2009) Endosomal Nox2 facilitates redox-dependent induction of NF-kappaB by TNF-alpha. Antioxid Redox Signal 11:1249-63
Oakley, Fredrick D; Abbott, Duane; Li, Qiang et al. (2009) Signaling components of redox active endosomes: the redoxosomes. Antioxid Redox Signal 11:1313-33
Oakley, Fredrick D; Smith, Rachel L; Engelhardt, John F (2009) Lipid rafts and caveolin-1 coordinate interleukin-1beta (IL-1beta)-dependent activation of NFkappaB by controlling endocytosis of Nox2 and IL-1beta receptor 1 from the plasma membrane. J Biol Chem 284:33255-64

Showing the most recent 10 out of 35 publications