Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
7R01DK051610-02
Application #
2518559
Study Section
General Medicine B Study Section (GMB)
Project Start
1996-09-01
Project End
2000-08-31
Budget Start
1997-07-01
Budget End
1997-08-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Anesthesiology
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Yamada, Toshiki; Strange, Kevin (2018) Intracellular and extracellular loops of LRRC8 are essential for volume-regulated anion channel function. J Gen Physiol 150:1003-1015
Yamada, Toshiki; Wondergem, Robert; Morrison, Rebecca et al. (2016) Leucine-rich repeat containing protein LRRC8A is essential for swelling-activated Cl- currents and embryonic development in zebrafish. Physiol Rep 4:
Yamada, Toshiki; Strange, Kevin (2016) Regulatory Conformational Coupling between CLC Anion Channel Membrane and Cytoplasmic Domains. Biophys J 111:1887-1896
Strange, Kevin (2016) Drug Discovery in Fish, Flies, and Worms. ILAR J 57:133-143
Yamada, Toshiki; Krzeminski, Mickael; Bozoky, Zoltan et al. (2016) Role of CBS and Bateman Domains in Phosphorylation-Dependent Regulation of a CLC Anion Channel. Biophys J 111:1876-1886
Branicky, Robyn; Miyazaki, Hiroaki; Strange, Kevin et al. (2014) The voltage-gated anion channels encoded by clh-3 regulate egg laying in C. elegans by modulating motor neuron excitability. J Neurosci 34:764-75
Yamada, Toshiki; Bhate, Manasi P; Strange, Kevin (2013) Regulatory phosphorylation induces extracellular conformational changes in a CLC anion channel. Biophys J 104:1893-904
Miyazaki, Hiroaki; Strange, Kevin (2012) Differential regulation of a CLC anion channel by SPAK kinase ortholog-mediated multisite phosphorylation. Am J Physiol Cell Physiol 302:C1702-12
Miyazaki, Hiroaki; Yamada, Toshiki; Parton, Angela et al. (2012) CLC anion channel regulatory phosphorylation and conserved signal transduction domains. Biophys J 103:1706-18
Strange, Kevin; Yin, Viravuth P (2012) Rhythmic Ca²? signaling: keeping time with microRNAs. Curr Biol 22:R1000-1

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