Although weight loss among overweight/obese individuals is relatively easy to achieve via low-energy diet, long-term maintenance of weight-loss has been less successful. In order to develop mechanisms for ensuring successful weight loss maintenance, it is important to understand the factors that contribute to both weight re-gain and weight maintenance following weight loss. The proposed study is a continuation of an ongoing study designed specifically to identify factors that contribute to both weight re-gain and successful weight maintenance following weight loss. This study will complete 4 years of follow-up evaluations on an established cohort of weight-reduced premenopausal African-American and Caucasian women. Study participants lost weight with either a low-energy diet protocol, a diet + aerobic training protocol, or a diet + resistance training protocol. Women were evaluated at baseline, following weight loss, and annully thereafter for body composition, fat distribution, physical fitness, total and activity-related energy expenditure (by doubly-labeled water), insulin sensitivity, and a number of risk factors for chronic metabolic disease. Baseline data are available on a total of 327 women; this project will complete the final evaluations on the final 76 women to undergo weight loss. At the termination of this project, 1-4 years of follow-up data will be available on -254women.
The Specific Aims of this project are: 1) Assess body composition, energy expenditure, physical fitness, and exercise difficulty annually among the established group of weight-reduced women; identify the extent to which free-living physical activity, exercise difficulty, and resting energy expenditure predict changes in body composition over time; 2) Assess body fat distribution, insulin sensitivity, lipids, and markers of inflammation annually among the established group of weight-reduced women; identify the extent to which total, visceral, and subcutaneous abdominal fat predicted changes in disease risk factors over time; 3) Assess lean body mass distribution (trunk vs limb) annually among the established group of weight-reduced women; identify the extent to which lean mass distribution predicts changes in resting energy expenditure over time; 4) Determine the contribution of ethnicity to observed relationships.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Research Project (R01)
Project #
Application #
Study Section
Special Emphasis Panel (ZRG1-EMNR-K (90))
Program Officer
Miles, Carolyn
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Alabama Birmingham
Schools of Allied Health Profes
United States
Zip Code
Sweatt, S Katherine; Roy, Jane; Chandler-Laney, Paula et al. (2016) Ethnic differences in the consistency and accuracy of perceived exertion. Am J Hum Biol 28:398-404
Cardel, Michelle; Lemas, Dominick J; Jackson, Kristina Harris et al. (2015) Higher Intake of PUFAs Is Associated with Lower Total and Visceral Adiposity and Higher Lean Mass in a Racially Diverse Sample of Children. J Nutr 145:2146-52
Hunter, Gary R; Neumeier, William H; Bickel, C Scott et al. (2014) Arterial elasticity, strength, fatigue, and endurance in older women. Biomed Res Int 2014:501754
Cardel, Michelle; Willig, Amanda L; Dulin-Keita, Akilah et al. (2014) Home-schooled children are thinner, leaner, and report better diets relative to traditionally schooled children. Obesity (Silver Spring) 22:497-503
Sriram, Neeraj; Hunter, Gary R; Fisher, Gordon et al. (2014) Resting energy expenditure and systolic blood pressure relationships in women across 4.5 years. J Clin Hypertens (Greenwich) 16:172-6
Hunter, Gary R; Plaisance, Eric P; Fisher, Gordon (2014) Weight loss and bone mineral density. Curr Opin Endocrinol Diabetes Obes 21:358-62
Kell, Kenneth P; Cardel, Michelle I; Bohan Brown, Michelle M et al. (2014) Added sugars in the diet are positively associated with diastolic blood pressure and triglycerides in children. Am J Clin Nutr 100:46-52
Hamilton, Kara C; Fisher, Gordon; Roy, Jane L et al. (2013) The effects of weight loss on relative bone mineral density in premenopausal women. Obesity (Silver Spring) 21:441-8
Corrick, Katie L; Hunter, Gary R; Fisher, Gordon et al. (2013) Changes in vascular hemodynamics in older women following 16 weeks of combined aerobic and resistance training. J Clin Hypertens (Greenwich) 15:241-6
Hunter, Gary R; Fisher, Gordon; Bryan, David R et al. (2012) Weight loss and exercise training effect on oxygen uptake and heart rate response to locomotion. J Strength Cond Res 26:1366-73

Showing the most recent 10 out of 75 publications