Although weight loss among overweight/obese individuals is relatively easy to achieve via low-energy diet, long-term maintenance of weight-loss has been less successful. In order to develop mechanisms for ensuring successful weight loss maintenance, it is important to understand the factors that contribute to both weight re-gain and weight maintenance following weight loss. The proposed study is a continuation of an ongoing study designed specifically to identify factors that contribute to both weight re-gain and successful weight maintenance following weight loss. This study will complete 4 years of follow-up evaluations on an established cohort of weight-reduced premenopausal African-American and Caucasian women. Study participants lost weight with either a low-energy diet protocol, a diet + aerobic training protocol, or a diet + resistance training protocol. Women were evaluated at baseline, following weight loss, and annully thereafter for body composition, fat distribution, physical fitness, total and activity-related energy expenditure (by doubly-labeled water), insulin sensitivity, and a number of risk factors for chronic metabolic disease. Baseline data are available on a total of 327 women; this project will complete the final evaluations on the final 76 women to undergo weight loss. At the termination of this project, 1-4 years of follow-up data will be available on -254women.
The Specific Aims of this project are: 1) Assess body composition, energy expenditure, physical fitness, and exercise difficulty annually among the established group of weight-reduced women; identify the extent to which free-living physical activity, exercise difficulty, and resting energy expenditure predict changes in body composition over time; 2) Assess body fat distribution, insulin sensitivity, lipids, and markers of inflammation annually among the established group of weight-reduced women; identify the extent to which total, visceral, and subcutaneous abdominal fat predicted changes in disease risk factors over time; 3) Assess lean body mass distribution (trunk vs limb) annually among the established group of weight-reduced women; identify the extent to which lean mass distribution predicts changes in resting energy expenditure over time; 4) Determine the contribution of ethnicity to observed relationships.
| Sweatt, S Katherine; Roy, Jane; Chandler-Laney, Paula et al. (2016) Ethnic differences in the consistency and accuracy of perceived exertion. Am J Hum Biol 28:398-404 |
| Cardel, Michelle; Lemas, Dominick J; Jackson, Kristina Harris et al. (2015) Higher Intake of PUFAs Is Associated with Lower Total and Visceral Adiposity and Higher Lean Mass in a Racially Diverse Sample of Children. J Nutr 145:2146-52 |
| Hunter, Gary R; Neumeier, William H; Bickel, C Scott et al. (2014) Arterial elasticity, strength, fatigue, and endurance in older women. Biomed Res Int 2014:501754 |
| Cardel, Michelle; Willig, Amanda L; Dulin-Keita, Akilah et al. (2014) Home-schooled children are thinner, leaner, and report better diets relative to traditionally schooled children. Obesity (Silver Spring) 22:497-503 |
| Sriram, Neeraj; Hunter, Gary R; Fisher, Gordon et al. (2014) Resting energy expenditure and systolic blood pressure relationships in women across 4.5 years. J Clin Hypertens (Greenwich) 16:172-6 |
| Hunter, Gary R; Plaisance, Eric P; Fisher, Gordon (2014) Weight loss and bone mineral density. Curr Opin Endocrinol Diabetes Obes 21:358-62 |
| Kell, Kenneth P; Cardel, Michelle I; Bohan Brown, Michelle M et al. (2014) Added sugars in the diet are positively associated with diastolic blood pressure and triglycerides in children. Am J Clin Nutr 100:46-52 |
| Hamilton, Kara C; Fisher, Gordon; Roy, Jane L et al. (2013) The effects of weight loss on relative bone mineral density in premenopausal women. Obesity (Silver Spring) 21:441-8 |
| Corrick, Katie L; Hunter, Gary R; Fisher, Gordon et al. (2013) Changes in vascular hemodynamics in older women following 16 weeks of combined aerobic and resistance training. J Clin Hypertens (Greenwich) 15:241-6 |
| Hunter, Gary R; Fisher, Gordon; Bryan, David R et al. (2012) Weight loss and exercise training effect on oxygen uptake and heart rate response to locomotion. J Strength Cond Res 26:1366-73 |
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