Abstract

Little is known concerning the susceptibility genes for autoimmune thyroid disease (AITD). However, epidemiologic evidence for a genetic susceptibility to AITD is abundant; the diseases cluster in families, they are more common in women, the concordance rate in monozygotic twins is up to 70 percent, and studies have demonstrated an association between AITD and certain HLA alleles.
The aim of this research proposal, therefore, is to detect the susceptibility genes for AITD. The applicants will achieve this aim by the use of highly polymorphic microsatellite-based whole genome screening of informative families with Graves' disease and/or Hashimoto's disease. To date, there has been only sparse modern research into the genetics of AITD because of the complex nature of the disorders. The applicants claim that their group is one of the few with previous experience in the analysis of families with AITD and they can now bring together their sources of well characterized families and expertise in the use of automated fluorescence-tagged microsatellite markers.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
1R01DK052464-01
Application #
2017976
Study Section
Endocrinology Study Section (END)
Program Officer
Akolkar, Beena
Project Start
1997-08-01
Project End
2001-06-30
Budget Start
1997-08-01
Budget End
1998-06-30
Support Year
1
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
Mount Sinai School of Medicine
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
114400633
City
New York
State
NY
Country
United States
Zip Code
10029

  Publications

Baliram, R; Latif, R; Morshed, S A et al. (2016) T3 Regulates a Human Macrophage-Derived TSH-? Splice Variant: Implications for Human Bone Biology. Endocrinology 157:3658-67
Latif, Rauf; Ali, M Rejwan; Mezei, Mihaly et al. (2015) Transmembrane domains of attraction on the TSH receptor. Endocrinology 156:488-98
Latif, Rauf; Ali, M Rejwan; Ma, Risheng et al. (2015) New small molecule agonists to the thyrotropin receptor. Thyroid 25:51-62
Morshed, S A; Davies, T F (2015) Graves' Disease Mechanisms: The Role of Stimulating, Blocking, and Cleavage Region TSH Receptor Antibodies. Horm Metab Res 47:727-34
Ma, Risheng; Minsky, Noga; Morshed, Syed A et al. (2014) Stemness in human thyroid cancers and derived cell lines: the role of asymmetrically dividing cancer stem cells resistant to chemotherapy. J Clin Endocrinol Metab 99:E400-9
Davies, Terry F; Ali, M Rejwan; Latif, Rauf (2014) Allosteric modulators hit the TSH receptor. Endocrinology 155:1-5
Yin, Xiaoming; Sachidanandam, Ravi; Morshed, Syed et al. (2014) mRNA-Seq reveals novel molecular mechanisms and a robust fingerprint in Graves' disease. J Clin Endocrinol Metab 99:E2076-83
Ma, Risheng; Latif, Rauf; Davies, Terry F (2013) Thyroid follicle formation and thyroglobulin expression in multipotent endodermal stem cells. Thyroid 23:385-91
Davies, Terry F (2013) Is thyroid transplantation on the distant horizon? Thyroid 23:139-41
Baliram, R; Chow, A; Huber, A K et al. (2013) Thyroid and bone: macrophage-derived TSH-? splice variant increases murine osteoblastogenesis. Endocrinology 154:4919-26

Showing the most recent 10 out of 84 publications