Little is known concerning the susceptibility genes for autoimmune thyroid disease (AITD). However, epidemiologic evidence for a genetic susceptibility to AITD is abundant; the diseases cluster in families, they are more common in women, the concordance rate in monozygotic twins is up to 70 percent, and studies have demonstrated an association between AITD and certain HLA alleles.
The aim of this research proposal, therefore, is to detect the susceptibility genes for AITD. The applicants will achieve this aim by the use of highly polymorphic microsatellite-based whole genome screening of informative families with Graves' disease and/or Hashimoto's disease. To date, there has been only sparse modern research into the genetics of AITD because of the complex nature of the disorders. The applicants claim that their group is one of the few with previous experience in the analysis of families with AITD and they can now bring together their sources of well characterized families and expertise in the use of automated fluorescence-tagged microsatellite markers.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Research Project (R01)
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Study Section
Endocrinology Study Section (END)
Program Officer
Akolkar, Beena
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Mount Sinai School of Medicine
Internal Medicine/Medicine
Schools of Medicine
New York
United States
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Baliram, R; Latif, R; Morshed, S A et al. (2016) T3 Regulates a Human Macrophage-Derived TSH-? Splice Variant: Implications for Human Bone Biology. Endocrinology 157:3658-67
Latif, Rauf; Ali, M Rejwan; Mezei, Mihaly et al. (2015) Transmembrane domains of attraction on the TSH receptor. Endocrinology 156:488-98
Latif, Rauf; Ali, M Rejwan; Ma, Risheng et al. (2015) New small molecule agonists to the thyrotropin receptor. Thyroid 25:51-62
Morshed, S A; Davies, T F (2015) Graves' Disease Mechanisms: The Role of Stimulating, Blocking, and Cleavage Region TSH Receptor Antibodies. Horm Metab Res 47:727-34
Ma, Risheng; Minsky, Noga; Morshed, Syed A et al. (2014) Stemness in human thyroid cancers and derived cell lines: the role of asymmetrically dividing cancer stem cells resistant to chemotherapy. J Clin Endocrinol Metab 99:E400-9
Davies, Terry F; Ali, M Rejwan; Latif, Rauf (2014) Allosteric modulators hit the TSH receptor. Endocrinology 155:1-5
Yin, Xiaoming; Sachidanandam, Ravi; Morshed, Syed et al. (2014) mRNA-Seq reveals novel molecular mechanisms and a robust fingerprint in Graves' disease. J Clin Endocrinol Metab 99:E2076-83
Davies, Terry F (2013) Is thyroid transplantation on the distant horizon? Thyroid 23:139-41
Baliram, R; Chow, A; Huber, A K et al. (2013) Thyroid and bone: macrophage-derived TSH-? splice variant increases murine osteoblastogenesis. Endocrinology 154:4919-26
Morshed, Syed A; Ma, Risheng; Latif, Rauf et al. (2013) How one TSH receptor antibody induces thyrocyte proliferation while another induces apoptosis. J Autoimmun 47:17-24

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