Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
7R01DK054452-02
Application #
6381232
Study Section
General Medicine A Subcommittee 2 (GMA)
Program Officer
Hamilton, Frank A
Project Start
2000-09-01
Project End
2004-08-31
Budget Start
2001-09-01
Budget End
2002-08-31
Support Year
2
Fiscal Year
2001
Total Cost
$230,872
Indirect Cost
Name
University of Pittsburgh
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Maharshak, Nitsan; Ryu, Hyungjin Sally; Fan, Ting-Jia et al. (2015) Escherichia coli heme oxygenase modulates host innate immune responses. Microbiol Immunol 59:452-65
Tilstra, Jeremy S; Gaddy, Daniel F; Zhao, Jing et al. (2014) Pharmacologic IKK/NF-?B inhibition causes antigen presenting cells to undergo TNF? dependent ROS-mediated programmed cell death. Sci Rep 4:3631
Steinbach, Erin C; Plevy, Scott E (2014) The role of macrophages and dendritic cells in the initiation of inflammation in IBD. Inflamm Bowel Dis 20:166-75
Onyiah, Joseph C; Sheikh, Shehzad Z; Maharshak, Nitsan et al. (2014) Heme oxygenase-1 and carbon monoxide regulate intestinal homeostasis and mucosal immune responses to the enteric microbiota. Gut Microbes 5:220-4
Steinbach, Erin C; Kobayashi, Taku; Russo, Steven M et al. (2014) Innate PI3K p110? regulates Th1/Th17 development and microbiota-dependent colitis. J Immunol 192:3958-68
Kobayashi, Taku; Steinbach, Erin C; Russo, Steven M et al. (2014) NFIL3-deficient mice develop microbiota-dependent, IL-12/23-driven spontaneous colitis. J Immunol 192:1918-27
Nighot, Prashant; Young, Karen; Nighot, Meghali et al. (2013) Chloride channel ClC-2 is a key factor in the development of DSS-induced murine colitis. Inflamm Bowel Dis 19:2867-77
Maseda, Damian; Candando, Kathleen M; Smith, Susan H et al. (2013) Peritoneal cavity regulatory B cells (B10 cells) modulate IFN-?+CD4+ T cell numbers during colitis development in mice. J Immunol 191:2780-2795
Lennon, E M; Maharshak, Nitsan; Elloumi, H et al. (2013) Early life stress triggers persistent colonic barrier dysfunction and exacerbates colitis in adult IL-10-/- mice. Inflamm Bowel Dis 19:712-9
Onyiah, Joseph C; Sheikh, Shehzad Z; Maharshak, Nitsan et al. (2013) Carbon monoxide and heme oxygenase-1 prevent intestinal inflammation in mice by promoting bacterial clearance. Gastroenterology 144:789-98

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