MORBIDITY AND MORTALITY RELATED TO GASTRIC BYPASS SURGERY This four-year renewal application will test the hypothesis that Roux-en-Y gastric bypass (RY-GBP) surgery reduces long-term (5 1/2-year follow-up) morbidity from severe obesity. This will be the first long-term controlled study of this procedure, which has tripled in use over the last four years and now comprises 93% of bariatric surgery in the U.S.In contrast to gastric banding, RY-GBP appears more likely to be associated with sustained weight loss and reduced morbidity at 5 years. Proof that RY-GBP produces long-term beneficial effects and reduces morbidity must be obtained before we can recommend the widespread use of this treatment for obesity. This is of urgency due to the rising epidemic of obesity and its sequelae (diabetes, hypertension, dyslipidemia, atherosclerosis), and due to the continuing absence of other effective long-term treatments for severe obesity. A 5 1/2-year follow-up is proposed in 924 severely obese subjects: 332 RY-GBP subjects, 336 control severely obese subjects seeking surgery but denied insurance coverage, and 256 random population severely obese controls. In the initial portion of this study, extensive characterization of these subjects at baseline and 2 years later (near the point of the greatest weight loss in the surgical subjects) was performed, including: body weight and composition, blood pressure, lipid profile, insulin resistance, resting metabolic rate, renal function, sleep apnea, echocardiogram, baseline and stress EGG, exercise treadmill fitness, physical activity, diet, and quality of life. All variables will be remeasured at 5 1/2 years to see if the 2-year morbidity reduction is maintained or further improved. Particular emphasis of the 5 1/2-year follow-up will be on echocardiographic changes that might lead to heart failure in the controls but be reversed in the surgical subjects. The two-year follow-up suggests beneficial effects of RY-GBP on cardiac structure and function; however, these changes may continue to evolve for several years. The proposed study which would be the largest of it's kind to date, will provide a wealth of data crucial for surgeons, their patients and policy makers regarding the long-term risks and benefits of RY-GBP surgery.
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| Priester, Tiffany; Ault, Travis G; Davidson, Lance et al. (2015) Coronary calcium scores 6 years after bariatric surgery. Obes Surg 25:90-6 |
| Adams, T D; Hammoud, A O; Davidson, L E et al. (2015) Maternal and neonatal outcomes for pregnancies before and after gastric bypass surgery. Int J Obes (Lond) 39:686-94 |
| Litwin, Sheldon E (2013) Diabetes and the heart: is there objective evidence of a human diabetic cardiomyopathy? Diabetes 62:3329-30 |
| Adams, Ted D; Davidson, Lance E; Litwin, Sheldon E et al. (2012) Health benefits of gastric bypass surgery after 6 years. JAMA 308:1122-31 |
| Kolotkin, Ronette L; Davidson, Lance E; Crosby, Ross D et al. (2012) Six-year changes in health-related quality of life in gastric bypass patients versus obese comparison groups. Surg Obes Relat Dis 8:625-33 |
| Adams, Ted D; Davidson, Lance E; Litwin, Sheldon E et al. (2012) Gastrointestinal surgery: cardiovascular risk reduction and improved long-term survival in patients with obesity and diabetes. Curr Atheroscler Rep 14:606-15 |
| Gabrielsen, J Scott; Gao, Yan; Simcox, Judith A et al. (2012) Adipocyte iron regulates adiponectin and insulin sensitivity. J Clin Invest 122:3529-40 |
| Kolotkin, Ronette L; LaMonte, Michael J; Walker, James M et al. (2011) Predicting sleep apnea in bariatric surgery patients. Surg Obes Relat Dis 7:605-10 |
| Hunt, Steven C; Hasstedt, Sandra J; Xin, Yuanpei et al. (2011) Polymorphisms in the NPY2R gene show significant associations with BMI that are additive to FTO, MC4R, and NPFFR2 gene effects. Obesity (Silver Spring) 19:2241-7 |
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