Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK057030-03
Application #
6476241
Study Section
Special Emphasis Panel (ZRG1-GMA-2 (02))
Program Officer
Hamilton, Frank A
Project Start
2000-04-01
Project End
2004-11-30
Budget Start
2001-12-01
Budget End
2002-11-30
Support Year
3
Fiscal Year
2002
Total Cost
$260,764
Indirect Cost
Name
Rhode Island Hospital (Providence, RI)
Department
Type
DUNS #
161202122
City
Providence
State
RI
Country
United States
Zip Code
02903
Rieder, Florian; Nonevski, Ilche; Ma, Jie et al. (2014) T-helper 2 cytokines, transforming growth factor ?1, and eosinophil products induce fibrogenesis and alter muscle motility in patients with eosinophilic esophagitis. Gastroenterology 146:1266-77.e1-9
Ma, Jie; Altomare, Annamaria; Guarino, Michele et al. (2012) HCl-induced and ATP-dependent upregulation of TRPV1 receptor expression and cytokine production by human esophageal epithelial cells. Am J Physiol Gastrointest Liver Physiol 303:G635-45
Altomare, A; Ma, J; Guarino, M P L et al. (2012) Platelet-activating factor and distinct chemokines are elevated in mucosal biopsies of erosive compared with non-erosive reflux disease patients and controls. Neurogastroenterol Motil 24:943-e463
Ma, Jie; Altomare, Annamaria; Rieder, Florian et al. (2011) ATP: a mediator for HCl-induced TRPV1 activation in esophageal mucosa. Am J Physiol Gastrointest Liver Physiol 301:G1075-82
Ma, Jie; Harnett, Karen M; Behar, Jose et al. (2010) Signaling in TRPV1-induced platelet activating factor (PAF) in human esophageal epithelial cells. Am J Physiol Gastrointest Liver Physiol 298:G233-40
Rieder, Florian; Biancani, Piero; Harnett, Karen et al. (2010) Inflammatory mediators in gastroesophageal reflux disease: impact on esophageal motility, fibrosis, and carcinogenesis. Am J Physiol Gastrointest Liver Physiol 298:G571-81
Guarino, M P L; Cheng, L; Ma, J et al. (2010) Increased TRPV1 gene expression in esophageal mucosa of patients with non-erosive and erosive reflux disease. Neurogastroenterol Motil 22:746-51, e219
Ma, Jie; Altomare, Annamaria; de la Monte, Suzanne et al. (2010) HCl-induced inflammatory mediators in esophageal mucosa increase migration and production of H2O2 by peripheral blood leukocytes. Am J Physiol Gastrointest Liver Physiol 299:G791-8
Cheng, Ling; de la Monte, Suzanne; Ma, Jie et al. (2009) HCl-activated neural and epithelial vanilloid receptors (TRPV1) in cat esophageal mucosa. Am J Physiol Gastrointest Liver Physiol 297:G135-43
Rieder, Florian; Cheng, Ling; Harnett, Karen M et al. (2007) Gastroesophageal reflux disease-associated esophagitis induces endogenous cytokine production leading to motor abnormalities. Gastroenterology 132:154-65

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