Abstract

The expression pattern of SRC3 will be established during development using the Lac-Z enzyme marker linked to the SRC3 promoter. The role of SRC3 in development will be addressed by examining the structural defects and functional disorders that occur in a recently developed SRC3 knockout mouse model and will include tests for viability, growth, fertility, endocrine regulation and steroid receptor function. The role of SRC3 in mammary gland development, differentiation, and function will be determined in the SRC3 knockout mice. To establish the function of SRC3 in breast cancer initiation and progression, breast cancer will be induced in transgenic knockout mice by tissue specific expression of transgenic oncogenes or treatment with chemical carcinogens. The role of SRC3 in androgen receptor mediated prostate growth and target gene expression will be investigated in the SRC3 knockout mice. It is hoped that these studies will reveal new molecular targets for the diagnosis and treatment of breast cancer.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK058242-04
Application #
6643313
Study Section
Biochemical Endocrinology Study Section (BCE)
Program Officer
Margolis, Ronald N
Project Start
2000-09-15
Project End
2005-08-31
Budget Start
2003-09-01
Budget End
2004-08-31
Support Year
4
Fiscal Year
2003
Total Cost
$224,250
Indirect Cost

  Institution

Name
Baylor College of Medicine
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
051113330
City
Houston
State
TX
Country
United States
Zip Code
77030

  Publications

Mo, Pingli; Zhou, Qiling; Guan, Lei et al. (2015) Amplified in breast cancer 1 promotes colorectal cancer progression through enhancing notch signaling. Oncogene 34:3935-3945
Scoville, David W; Cyphert, Holly A; Liao, Lan et al. (2015) MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB Transcription Factors to Regulate Islet ?-Cell Function. Diabetes 64:3772-83
Chen, Xian; Qin, Li; Liu, Zhaoliang et al. (2015) Knockout of SRC-1 and SRC-3 in Mice Decreases Cardiomyocyte Proliferation and Causes a Noncompaction Cardiomyopathy Phenotype. Int J Biol Sci 11:1056-72
Ma, Gang; He, Jianjun; Yu, Yang et al. (2015) Tamoxifen inhibits ER-negative breast cancer cell invasion and metastasis by accelerating Twist1 degradation. Int J Biol Sci 11:618-28
Liu, Zhaoliang; Chen, Xian; Zhou, Suoling et al. (2015) The histone H3K9 demethylase Kdm3b is required for somatic growth and female reproductive function. Int J Biol Sci 11:494-507
Tien, Jean Ching-Yi; Liao, Lan; Liu, Yonghong et al. (2014) The steroid receptor coactivator-3 is required for developing neuroendocrine tumor in the mouse prostate. Int J Biol Sci 10:1116-27
Lee, Dong-Kee; Liu, Yonghong; Liao, Lan et al. (2014) The prostate basal cell (BC) heterogeneity and the p63-positive BC differentiation spectrum in mice. Int J Biol Sci 10:1007-17
Qin, Li; Wu, Ye-Lin; Toneff, Michael J et al. (2014) NCOA1 Directly Targets M-CSF1 Expression to Promote Breast Cancer Metastasis. Cancer Res 74:3477-88
Xu, Yan; Xu, Yixiang; Liao, Lan et al. (2013) Inducible knockout of Twist1 in young and adult mice prolongs hair growth cycle and has mild effects on general health, supporting Twist1 as a preferential cancer target. Am J Pathol 183:1281-1292
York, Brian; Sagen, Jørn V; Tsimelzon, Anna et al. (2013) Research resource: tissue- and pathway-specific metabolomic profiles of the steroid receptor coactivator (SRC) family. Mol Endocrinol 27:366-80

Showing the most recent 10 out of 59 publications