Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
3R01DK064819-01S1
Application #
6838407
Study Section
Endocrinology Study Section (END)
Program Officer
Sato, Sheryl M
Project Start
2003-07-01
Project End
2008-05-31
Budget Start
2003-07-01
Budget End
2004-05-31
Support Year
1
Fiscal Year
2004
Total Cost
$48,094
Indirect Cost
Name
Columbia University (N.Y.)
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Kitamoto, Takumi; Sakurai, Kenichi; Lee, Eun Young et al. (2018) Distinct roles of systemic and local actions of insulin on pancreatic ?-cells. Metabolism 82:100-110
Accili, Domenico (2018) Insulin Action Research and the Future of Diabetes Treatment: The 2017 Banting Medal for Scientific Achievement Lecture. Diabetes 67:1701-1709
Haeusler, Rebecca A; McGraw, Timothy E; Accili, Domenico (2018) Biochemical and cellular properties of insulin receptor signalling. Nat Rev Mol Cell Biol 19:31-44
Ishida, Emi; Kim-Muller, Ja Young; Accili, Domenico (2017) Pair Feeding, but Not Insulin, Phloridzin, or Rosiglitazone Treatment, Curtails Markers of ?-Cell Dedifferentiation in db/db Mice. Diabetes 66:2092-2101
Langlet, Fanny; Haeusler, Rebecca A; Lindén, Daniel et al. (2017) Selective Inhibition of FOXO1 Activator/Repressor Balance Modulates Hepatic Glucose Handling. Cell 171:824-835.e18
Kim-Muller, Ja Young; Fan, Jason; Kim, Young Jung R et al. (2016) Aldehyde dehydrogenase 1a3 defines a subset of failing pancreatic ? cells in diabetic mice. Nat Commun 7:12631
Kim-Muller, Ja Young; Kim, Young Jung R; Fan, Jason et al. (2016) FoxO1 Deacetylation Decreases Fatty Acid Oxidation in ?-Cells and Sustains Insulin Secretion in Diabetes. J Biol Chem 291:10162-72
Cinti, Francesca; Bouchi, Ryotaro; Kim-Muller, Ja Young et al. (2016) Evidence of ?-Cell Dedifferentiation in Human Type 2 Diabetes. J Clin Endocrinol Metab 101:1044-54
Accili, D; Talchai, S C; Kim-Muller, J Y et al. (2016) When ?-cells fail: lessons from dedifferentiation. Diabetes Obes Metab 18 Suppl 1:117-22
Kuo, Taiyi; Kim-Muller, Ja Young; McGraw, Timothy E et al. (2016) Altered Plasma Profile of Antioxidant Proteins as an Early Correlate of Pancreatic ? Cell Dysfunction. J Biol Chem 291:9648-56

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