Bariatric surgery is emerging as a safe and efficacious treatment for adolescent severe obesity, yet the durability of improvements and impact on patient well-being in the longer-term is largely unknown. This is a critical gap given adult evidence that patterns of optimal and suboptimal weight loss outcomes extend across the first post-operative decade or more, as well as by increased rates of alcohol use disorder (AUD) and risk of death by suicide. Unlike an adult, the adolescent patient's post-operative course cuts across known developmental periods where mental health disorders first emerge, and high risk behavior engagement peaks, including alcohol/tobacco/drug use, HIV/sexual-risk behaviors, and suicidal behaviors. Hence, tracking only adolescent physical health outcomes following bariatric surgery does not sufficiently capture the

Public Health Relevance

/Relevance to Public Health: Bariatric surgery is emerging as a safe and efficacious treatment for adolescent severe obesity, yet the durability of improvements and impact on patient well-being in the longer- term is largely unknown. Unique to the adolescent (vs. adult) patient is a post-operative course that cuts across transitional developmental periods, where mental health disorders, HIV/sexual-risk behaviors, alcohol/tobacco/drug use, and suicide risks are high priority health issues, and from which this patient group is not spared. Successful completion of the proposed controlled longitudinal observational (continuation) study of the adolescent patient with severe obesity who underwent bariatric surgery will reveal 10-year, young adult outcomes of these public health priorities in the context of weight loss, weight status, physical health, and quality of life to inform clinical practice guidelines for this specific age group and vulnerable population.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK080020-12
Application #
9938559
Study Section
Special Emphasis Panel (ZDK1)
Program Officer
Evans, Mary
Project Start
2008-03-01
Project End
2024-05-31
Budget Start
2020-06-01
Budget End
2021-05-31
Support Year
12
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Cincinnati Children's Hospital Medical Center
Department
Type
DUNS #
071284913
City
Cincinnati
State
OH
Country
United States
Zip Code
45229
Hunsaker, Sanita L; Garland, Beth H; Rofey, Dana et al. (2018) A Multisite 2-Year Follow Up of Psychopathology Prevalence, Predictors, and Correlates Among Adolescents Who Did or Did Not Undergo Weight Loss Surgery. J Adolesc Health 63:142-150
Becnel, J N; Zeller, M H; Noll, J G et al. (2017) Romantic, sexual, and sexual risk behaviours of adolescent females with severe obesity. Pediatr Obes 12:388-397
Zeller, Meg H; Washington, Gia A; Mitchell, James E et al. (2017) Alcohol use risk in adolescents 2 years after bariatric surgery. Surg Obes Relat Dis 13:85-94
Reiter-Purtill, Jennifer; Gowey, Marissa A; Austin, Heather et al. (2017) Peer Victimization in Adolescents With Severe Obesity: The Roles of Self-Worth and Social Support in Associations With Psychosocial Adjustment. J Pediatr Psychol 42:272-282
Zeller, Meg H; Hunsaker, Sanita; Mikhail, Carmen et al. (2016) Family factors that characterize adolescents with severe obesity and their role in weight loss surgery outcomes. Obesity (Silver Spring) 24:2562-2569
Zeller, Meg H; Becnel, Jennifer; Reiter-Purtill, Jennifer et al. (2016) Associations Among Excess Weight Status and Tobacco, Alcohol, and Illicit Drug Use in a Large National Sample of Early Adolescent Youth. Prev Sci 17:483-92
Gowey, Marissa A; Reiter-Purtill, Jennifer; Becnel, Jennifer et al. (2016) Weight-related correlates of psychological dysregulation in adolescent and young adult (AYA) females with severe obesity. Appetite 99:211-218
Zeller, Meg H; Reiter-Purtill, Jennifer; Peugh, James L et al. (2015) Youth Whose Weight Exceeds Healthy Guidelines Are High-Risk Targets for Tobacco Prevention Messaging and Close Monitoring of Cigarette Use. Child Obes 11:406-14
Zeller, Meg H; Noll, Jennie G; Sarwer, David B et al. (2015) Child Maltreatment and the Adolescent Patient With Severe Obesity: Implications for Clinical Care. J Pediatr Psychol 40:640-8
Rofey, Dana L; Zeller, Meg H; Brode, Cassie et al. (2015) A multisite view of psychosocial risks in patients presenting for bariatric surgery. Obesity (Silver Spring) 23:1218-25

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