The broad, long-term objective of this work is to develop novel, time-efficient methods for MR data acquisition and corresponding real-time signal processing techniques to allow formation of MR images which portray the cardiovascular system with high spatial resolution. This is significant due to the high incidence of cardiovascular disease.
Specific aims to be studied in this work are: 1. Modified Elliptical Centric (EC) Acquisition Techniques. The EC view order will be combined with projection reconstruction (PR) k-space sampling to exploit the intrinsic advantages of both approaches. Variants of the EC-PR technique will be developed to provide: (i) improved resolution for given time using 2D homodyne (HD) reconstruction; (ii) time-resolved studies with frame rates as high as 2 Hz; (iii) compatibility with parallel imaging methods such as SENSE for 4-fold reduction in scan time; and (iv) compatibility with a combination of SENSE and HD reconstruction for 6-fold scan time reduction for given resolution. The new methods will be applied to contrast-enhanced as well as non-contrast-enhanced MRA studies. 2. Real-Time Bolus Detection and Tracking. Means will be developed to detect and track contrast bolus transit in real time in a totally automated way as it moves through the vasculature over an extended field of view. This information will allow the generation of patient-specific bolus velocity profiles which can guide the MR angiographic pulse sequence and control table velocity and optimize spatial resolution on a patient- specific basis. 3. The Comprehensive Neurovascular Examination. The new acquisition and real-time computation techniques of Aims 1 and 2 will be integrated to provide a comprehensive angiogram of the aortic arch and great vessels, the carotid bifurcations, the intracranial arteries, and the draining veins of the brain following a single injection of contrast. Modest table motion during the exam will permit imaging of the extended FOV. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Research Project (R01)
Project #
2R01EB000212-20
Application #
7038454
Study Section
Biomedical Imaging Technology Study Section (BMIT)
Program Officer
Mclaughlin, Alan Charles
Project Start
1984-08-01
Project End
2010-03-31
Budget Start
2006-05-01
Budget End
2007-03-31
Support Year
20
Fiscal Year
2006
Total Cost
$375,551
Indirect Cost
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
006471700
City
Rochester
State
MN
Country
United States
Zip Code
55905
Stinson, Eric G; Trzasko, Joshua D; Campeau, Norbert G et al. (2018) Time-resolved contrast-enhanced MR angiography with single-echo Dixon fat suppression. Magn Reson Med 80:1556-1567
Kargar, Soudabeh; Borisch, Eric A; Froemming, Adam T et al. (2018) Robust and efficient pharmacokinetic parameter non-linear least squares estimation for dynamic contrast enhanced MRI of the prostate. Magn Reson Imaging 48:50-61
Riederer, Stephen J; Stinson, Eric G; Weavers, Paul T (2018) Technical Aspects of Contrast-enhanced MR Angiography: Current Status and New Applications. Magn Reson Med Sci 17:3-12
Riederer, Stephen J; Borisch, Eric A; Froemming, Adam T et al. (2017) Improved performance of prostate DCE-MRI using a 32-coil vs. 12-coil receiver array. Magn Reson Imaging 39:15-23
Stinson, Eric G; Trzasko, Joshua D; Fletcher, Joel G et al. (2017) Dual echo Dixon imaging with a constrained phase signal model and graph cuts reconstruction. Magn Reson Med 78:2203-2215
Weavers, Paul T; Borisch, Eric A; Hulshizer, Tom C et al. (2016) Improved receiver arrays and optimized parallel imaging accelerations applied to time-resolved 3D fluoroscopically tracked peripheral runoff CE-MRA. Magn Reson Imaging 34:280-8
Riederer, Stephen J; Haider, Clifton R; Borisch, Eric A et al. (2015) Recent advances in 3D time-resolved contrast-enhanced MR angiography. J Magn Reson Imaging 42:3-22
Weavers, Paul T; Borisch, Eric A; Riederer, Stephen J (2015) Selection and evaluation of optimal two-dimensional CAIPIRINHA kernels applied to time-resolved three-dimensional CE-MRA. Magn Reson Med 73:2234-42
Stinson, Eric G; Trzasko, Joshua D; Weavers, Paul T et al. (2015) Dixon-type and subtraction-type contrast-enhanced magnetic resonance angiography: A theoretical and experimental comparison of SNR and CNR. Magn Reson Med 74:81-92
Weavers, Paul T; Borisch, Eric A; Johnson, Casey P et al. (2014) Acceleration apportionment: a method of improved 2D SENSE acceleration applied to 3D contrast-enhanced MR angiography. Magn Reson Med 71:672-80

Showing the most recent 10 out of 49 publications