This proposal focuses on development of technology that is suited for both ultra-high resolution animal imaging systems and other high resolution applications such as human breast and head imaging. An integral part of our work to date is the development of a highly modular approach to the detectors and supporting electronics. This approach assures that imaging resources built using the technology can easily adapt to the changing demands of the biological research. In the previous funding period cost effective designs of detector modules, electronics, and reconstruction algorithms to provide ~ 1mm3 volume resolution were completed. In this renewal application, we propose to further develop detector modules, electronics, and reconstruction algorithms to support a depth-of-interaction design (dMiCE) that is an extension of our MiCES system designs. A major focus is on cost effective designs, and therefore our dMiCE module is based on a single-ended readout of light with light sharing between pairs of crystals to provide the depth-of-interaction (DOI) information. The proposal includes a careful optimization of light sharing techniques; investigation of multi-anode photomultiplier tubes (PMTs), position sensitive PMTs, and pixelated and position sensitive avalanche photodiodes as photoreceptors; new electronics designs moving essentially all pulse processing (integration, pileup correction/prevention, timing pickoff) into field programmable gate arrays (FPGAs); and extensions of our reconstruction algorithms to support DOI. The overall goal is to achieve spatial resolutions < 1.2 mm with sensitivity in a typical small animal configuration of > 15%. The effort will also include the development of maximum likelihood estimators for crystal-of-interaction and depth-of-interaction in segmented crystal module designs as well as better methods for optimization of our DOI approach. An important aspect of the work is to extend the DOI designs to investigate potential applications in time- of-flight (TOP) systems by both implementing FPGA based electronics that can provide timing resolutions of ~300 ps (the best values reported for current scintillators/PMTs for practical tomograph designs) and utilize DOI based TOP correction to improve the overall timing resolution of potential TOP scanner designs. The net result of our work will be contributions to the general knowledge of options for detector and electronics design for high-resolution detector systems as well as insight into methods to optimize TOP performance for different detector module designs. ? ? ?
| Dey, Samrat; Rudell, Jacques C; Lewellen, Thomas K et al. (2017) A CMOS Front-End Interface ASIC for SiPM-based Positron Emission Tomography Imaging Systems. IEEE Biomed Circuits Syst Conf 2017: |
| Hunter, William C J; Miyaoka, Robert S; MacDonald, Lawrence et al. (2015) Light-Sharing Interface for dMiCE Detectors Using Sub-Surface Laser Engraving. IEEE Trans Nucl Sci 62:27-35 |
| Pierce, L A; Hunter, W C J; Haynor, D R et al. (2014) Multiplexing strategies for monolithic crystal PET detector modules. Phys Med Biol 59:5347-60 |
| Hunter, William C J; Miyaoka, Robert S; MacDonald, Lawrence et al. (2013) Light-Sharing Interface for dMiCE Detectors using Sub-Surface Laser Engraving. IEEE Nucl Sci Symp Conf Rec (1997) 2013:1-7 |
| Li, Xiaoli; Alessio, Adam M; Burnett, Thompson H et al. (2013) Performance Evaluation of Small Animal PET Scanners With Different System Designs. IEEE Trans Nucl Sci 60: |
| Hunter, William C J; Barrett, Harrison H; Muzi, John P et al. (2013) SCOUT: a fast Monte-Carlo modeling tool of scintillation camera output. Phys Med Biol 58:3581-98 |
| Hunter, William C J; Barrett, Harrison H; Lewellen, Tom K et al. (2013) Multiple-hit parameter estimation in monolithic detectors. IEEE Trans Med Imaging 32:329-37 |
| Dey, Samrat; Lewellen, Thomas K; Miyaoka, Robert S et al. (2012) Impact of Analog IC Impairments in SiPM Interface Electronics. IEEE Trans Nucl Sci 2012:3572-3574 |
| Dey, Samrat; Lewellen, Thomas K; Miyaoka, Robert S et al. (2012) Highly-Integrated CMOS Interface Circuits for SiPM-Based PET Imaging Systems. IEEE Nucl Sci Symp Conf Rec (1997) :3556-3559 |
| Lewellen, Tom K; Dewitt, Don; Miyaoka, Robert S et al. (2012) A Building Block for Nuclear Medicine Imaging Systems Data Acquisition. IEEE Trans Nucl Sci : |
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