The goal of this proposal is to develop and validate a comprehensive examination of osteoarthritis. Osteoarthritis is a leading cause of chronic disability on the United States, affecting approximately 10% of those over 30 years old. Over the past 20 years, study of osteoarthritis with imaging has been primarily limited to evaluation with radiography. Magnetic Resonance Imaging (MRI), with its multi-planar capability and multiple contrast mechanisms, has emerged as the most promising non-invasive method to study osteoarthritis. The examination of osteoarthritis includes easement of articular cartilage integrity as well as other important structures. Osteoarthritis affects many joints, but is most evident in the knee. MRI has the potential to non-invasively evaluate both cartilage morphology and physiology, which is crucial to follow the effects of new osteoarthritis therapies. Current methods, however, suffer from long scan times that limit the amount of information that can be acquired in a reasonable examination time. As a result, there is a gap between what is feasible and what is currently applied in osteoarthritis studies. Our goal in this proposal is to eliminate the gap between the potential of MRI and current practice in evaluation of articular cartilage in osteoarthritis. Our group has pioneered many of the components that will be useful in the comprehensive evaluation of cartilage morphology and physiology in osteoarthritis, including rapid imaging of cartilage structure and rapid relaxation time measurements. In this proposal we will integrate those components and validate them into a comprehensive thirty-minute knee MRI exam for osteoarthritis progression.
| Yoder, James S; Kogan, Feliks; Gold, Garry E (2018) PET-MRI for the Study of Metabolic Bone Disease. Curr Osteoporos Rep 16:665-673 |
| Kogan, F; Fan, A P; Monu, U et al. (2018) Quantitative imaging of bone-cartilage interactions in ACL-injured patients with PET-MRI. Osteoarthritis Cartilage 26:790-796 |
| Halilaj, E; Hastie, T J; Gold, G E et al. (2018) Physical activity is associated with changes in knee cartilage microstructure. Osteoarthritis Cartilage 26:770-774 |
| Kogan, Feliks; Levine, Evan; Chaudhari, Akshay S et al. (2018) Simultaneous bilateral-knee MR imaging. Magn Reson Med 80:529-537 |
| Kogan, Feliks; Broski, Stephen M; Yoon, Daehyun et al. (2018) Applications of PET-MRI in musculoskeletal disease. J Magn Reson Imaging 48:27-47 |
| Chaudhari, Akshay S; Fang, Zhongnan; Kogan, Feliks et al. (2018) Super-resolution musculoskeletal MRI using deep learning. Magn Reson Med 80:2139-2154 |
| Chaudhari, Akshay S; Black, Marianne S; Eijgenraam, Susanne et al. (2018) Five-minute knee MRI for simultaneous morphometry and T2 relaxometry of cartilage and meniscus and for semiquantitative radiological assessment using double-echo in steady-state at 3T. J Magn Reson Imaging 47:1328-1341 |
| Chaudhari, Akshay S; Sveinsson, Bragi; Moran, Catherine J et al. (2017) Imaging and T2 relaxometry of short-T2 connective tissues in the knee using ultrashort echo-time double-echo steady-state (UTEDESS). Magn Reson Med 78:2136-2148 |
| Kogan, Feliks; Hargreaves, Brian A; Gold, Garry E (2017) Volumetric multislice gagCEST imaging of articular cartilage: Optimization and comparison with T1rho. Magn Reson Med 77:1134-1141 |
| Sveinsson, B; Chaudhari, A S; Gold, G E et al. (2017) A simple analytic method for estimating T2 in the knee from DESS. Magn Reson Imaging 38:63-70 |
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