Abstract

Cadmium is an environmental pollutant which has been shown to be toxic to a number of tissues in mammalian systems. These studies will make clear what dose is necessary to produce injury to the various tissues, which tissue is most sensitive to cadmium, and if there is a marked difference in the toxic sign between animals that receive one high, single dose and those that receive multiple, low doses over a long time. Information will be gained on the importance of metallothionein on the toxicity of cadmium. Does metallothionein alter the distribution of cadmium? Do metallothionein and cadmium levels in the tissues continue to rise with prolonged administration at different doses, or is a plateau achieved? What is the mechanism by which cadmium is excreted into the bile? Can it be enhanced by treatment with microsomal enzyme inducers? Will interruption of the enterohepatic circulation increase the elimination of cadmium from the body? If we can answer these very basic questions, then we should be able to treat cadmium poisoning on a more informed basis.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES001142-11
Application #
3249503
Study Section
Toxicology Study Section (TOX)
Project Start
1975-06-23
Project End
1988-05-31
Budget Start
1985-06-01
Budget End
1986-05-31
Support Year
11
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of Kansas
Department
Type
Schools of Medicine
DUNS #
016060860
City
Kansas City
State
KS
Country
United States
Zip Code
66160

  Publications

Klaassen, Curtis D; Reisman, Scott A (2010) Nrf2 the rescue: effects of the antioxidative/electrophilic response on the liver. Toxicol Appl Pharmacol 244:57-65
Liu, Jie; Kadiiska, Maria B; Corton, J Christopher et al. (2002) Acute cadmium exposure induces stress-related gene expression in wild-type and metallothionein-I/II-null mice. Free Radic Biol Med 32:525-35
Harstad, Eric B; Klaassen, Curtis D (2002) Analysis of strain difference in sensitivity to cadmium-induced hepatotoxicity in Fischer 344 and Sprague-Dawley rats. Toxicol Sci 67:329-40
Park, Jung D; Cherrington, Nathan J; Klaassen, Curtis D (2002) Intestinal absorption of cadmium is associated with divalent metal transporter 1 in rats. Toxicol Sci 68:288-94
Park, Jung D; Habeebu, Sultan S M; Klaassen, Curtis D (2002) Testicular toxicity of di-(2-ethylhexyl)phthalate in young Sprague-Dawley rats. Toxicology 171:105-15
Harstad, Eric B; Klaassen, Curtis D (2002) Gadolinium chloride pretreatment prevents cadmium chloride-induced liver damage in both wild-type and MT-null mice. Toxicol Appl Pharmacol 180:178-85
Leazer, Tyra M; Liu, Yaping; Klaassen, Curtis D (2002) Cadmium absorption and its relationship to divalent metal transporter-1 in the pregnant rat. Toxicol Appl Pharmacol 185:18-24
Harstad, Eric B; Klaassen, Curtis D (2002) iNOS-null mice are not resistant to cadmium chloride-induced hepatotoxicity. Toxicology 175:83-90
Harstad, Eric B; Klaassen, Curtis D (2002) Tumor necrosis factor-alpha-null mice are not resistant to cadmium chloride-induced hepatotoxicity. Toxicol Appl Pharmacol 179:155-62
Park, J D; Liu, Y; Klaassen, C D (2001) Protective effect of metallothionein against the toxicity of cadmium and other metals(1). Toxicology 163:93-100

Showing the most recent 10 out of 116 publications