Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
2R01ES003257-11
Application #
2153267
Study Section
Chemical Pathology Study Section (CPA)
Project Start
1984-01-01
Project End
2000-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
11
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Institute for Cancer Prevention
Department
Type
DUNS #
City
Valhalla
State
NY
Country
United States
Zip Code
10595
Sodum, R S; Fiala, E S (2001) Analysis of peroxynitrite reactions with guanine, xanthine, and adenine nucleosides by high-pressure liquid chromatography with electrochemical detection: C8-nitration and -oxidation. Chem Res Toxicol 14:438-50
Sodum, R S; Akerkar, S A; Fiala, E S (2000) Determination of 3-nitrotyrosine by high-pressure liquid chromatography with a dual-mode electrochemical detector. Anal Biochem 280:278-85
Sohn, O S; Fiala, E S (2000) Analysis of nitrite/nitrate in biological fluids: denitrification of 2-nitropropane in F344 rats. Anal Biochem 279:202-8
Sodum, R S; Fiala, E S (1998) N2-amination of guanine to 2-hydrazinohypoxanthine, a novel in vivo nucleic acid modification produced by the hepatocarcinogen 2-nitropropane. Chem Res Toxicol 11:1453-9
Fiala, E S; Sohn, O S; Li, H et al. (1997) Inhibition of 2-nitropropane-induced rat liver DNA and RNA damage by benzyl selenocyanate. Carcinogenesis 18:1809-15
Sodum, R S; Fiala, E S (1997) Amination of tyrosine in liver cytosol protein of male F344 rats treated with 2-nitropropane, 2-nitrobutane, 3-nitropentane, or acetoxime. Chem Res Toxicol 10:1420-6
Fiala, E S; Sodum, R S; Hussain, N S et al. (1995) Secondary nitroalkanes: induction of DNA repair in rat hepatocytes, activation by aryl sulfotransferase and hepatocarcinogenicity of 2-nitrobutane and 3-nitropentane in male F344 rats. Toxicology 99:89-97
Sodum, R S; Sohn, O S; Nie, G et al. (1994) Activation of the liver carcinogen 2-nitropropane by aryl sulfotransferase. Chem Res Toxicol 7:344-51
Sodum, R S; Nie, G; Fiala, E S (1993) 8-Aminoguanine: a base modification produced in rat liver nucleic acids by the hepatocarcinogen 2-nitropropane. Chem Res Toxicol 6:269-76
Swenson, D H; el-Bayoumy, K; Shuie, G H et al. (1993) Synthesis of N-(purin-8-yl)arylamines. Chem Res Toxicol 6:480-5

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