Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
3R01ES003356-06S1
Application #
3250591
Study Section
Toxicology Study Section (TOX)
Project Start
1989-07-01
Project End
1992-04-30
Budget Start
1989-07-01
Budget End
1990-04-30
Support Year
6
Fiscal Year
1989
Total Cost
Indirect Cost
Name
University of Arizona
Department
Type
Schools of Arts and Sciences
DUNS #
City
Tucson
State
AZ
Country
United States
Zip Code
85722
Fang, X; Hua, F; Fernando, Q (1996) Comparison of rac- and meso-2,3-dimercaptosuccinic acids for chelation of mercury and cadmium using chemical speciation models. Chem Res Toxicol 9:284-90
Fang, X; Fernando, Q (1995) Stereoisomeric selectivity of 2,3-dimercaptosuccinic acids in chelation therapy for lead poisoning. Chem Res Toxicol 8:525-36
Hurlbut, K M; Maiorino, R M; Mayersohn, M et al. (1994) Determination and metabolism of dithiol chelating agents. XVI: Pharmacokinetics of 2,3-dimercapto-1-propanesulfonate after intravenous administration to human volunteers. J Pharmacol Exp Ther 268:662-8
Fang, X; Fernando, Q (1994) Synthesis, structure, and properties of rac-2,3-dimercaptosuccinic acid, a potentially useful chelating agent for toxic metals. Chem Res Toxicol 7:148-56
Fang, X; Fernando, Q (1994) Conformations of zinc chelates of meso- and rac-2,3-dimercaptosuccinic acid in aqueous solution. Chem Res Toxicol 7:882-90
Fang, X; Fernando, Q (1994) A comparative study of meso- and rac-2,3-dimercaptosuccinic acids and their zinc complexes in aqueous solution. Chem Res Toxicol 7:770-8
Aposhian, H V; Levine, D J; Rivera, M et al. (1993) Determination and metabolism of dithiol chelating agents: the zinc chelate of the dimethyl ester of meso-2,3-dimercaptosuccinic acid increase biliary excretion of cadmium and platinum. Chem Res Toxicol 6:208-14
Maiorino, R M; Aposhian, M M; Xu, Z F et al. (1993) Determination and metabolism of dithiol chelating agents. XV. The meso-2,3-dimercaptosuccinic acid-cysteine (1:2) mixed disulfide, a major urinary metabolite of DMSA in the human, increases the urinary excretion of lead in the rat. J Pharmacol Exp Ther 267:1221-6
Aposhian, H V; Maiorino, R M; Rivera, M et al. (1992) Human studies with the chelating agents, DMPS and DMSA. J Toxicol Clin Toxicol 30:505-28
Akins, J M; Schroeder, J A; Brower, D L et al. (1992) Evaluation of Drosophila melanogaster as an alternative animal for studying the neurotoxicity of heavy metals. Biometals 5:111-20

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