Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
2R01ES003775-10
Application #
2153434
Study Section
Metabolic Pathology Study Section (MEP)
Project Start
1985-06-30
Project End
2000-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Boston University
Department
Type
Schools of Arts and Sciences
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118
Sholder, Gabriel; Creech, Amanda; Loechler, Edward L (2015) How Y-Family DNA polymerase IV is more accurate than Dpo4 at dCTP insertion opposite an N2-dG adduct of benzo[a]pyrene. DNA Repair (Amst) 35:144-53
Sholder, Gabriel; Loechler, Edward L (2015) A method to accurately quantitate intensities of (32)P-DNA bands when multiple bands appear in a single lane of a gel is used to study dNTP insertion opposite a benzo[a]pyrene-dG adduct by Sulfolobus DNA polymerases Dpo4 and Dbh. DNA Repair (Amst) 25:97-103
Ikeda, Mio; Furukohri, Asako; Philippin, Gaelle et al. (2014) DNA polymerase IV mediates efficient and quick recovery of replication forks stalled at N2-dG adducts. Nucleic Acids Res 42:8461-72
Chandani, Sushil; Loechler, Edward L (2013) Structural model of the Y-Family DNA polymerase V/RecA mutasome. J Mol Graph Model 39:133-44
Seo, Kwang Young; Yin, Jun; Donthamsetti, Prashant et al. (2009) Amino acid architecture that influences dNTP insertion efficiency in Y-family DNA polymerase V of E. coli. J Mol Biol 392:270-82
Chandani, Sushil; Loechler, Edward L (2009) Y-Family DNA polymerases may use two different dNTP shapes for insertion: a hypothesis and its implications. J Mol Graph Model 27:759-69
Clapp, Richard W; Jacobs, Molly M; Loechler, Edward L (2008) Environmental and occupational causes of cancer: new evidence 2005-2007. Rev Environ Health 23:1-37
Herscovitch, Melanie; Comb, William; Ennis, Thomas et al. (2008) Intermolecular disulfide bond formation in the NEMO dimer requires Cys54 and Cys347. Biochem Biophys Res Commun 367:103-8
Chandani, Sushil; Loechler, Edward L (2007) Molecular modeling benzo[a]pyrene N2-dG adducts in the two overlapping active sites of the Y-family DNA polymerase Dpo4. J Mol Graph Model 25:658-70
Kalam, M Abul; Haraguchi, Kazuhiro; Chandani, Sushil et al. (2006) Genetic effects of oxidative DNA damages: comparative mutagenesis of the imidazole ring-opened formamidopyrimidines (Fapy lesions) and 8-oxo-purines in simian kidney cells. Nucleic Acids Res 34:2305-15

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