Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
1R01ES003938-01
Application #
3251681
Study Section
Pharmacology A Study Section (PHRA)
Project Start
1986-01-01
Project End
1988-12-31
Budget Start
1986-01-01
Budget End
1986-12-31
Support Year
1
Fiscal Year
1986
Total Cost
Indirect Cost
Name
University of Medicine & Dentistry of NJ
Department
Type
Schools of Medicine
DUNS #
605799469
City
Newark
State
NJ
Country
United States
Zip Code
07107
Hong, J Y; Wang, Y Y; Mohr, S N et al. (2001) Human cytochrome P450 isozymes in metabolism and health effects of gasoline ethers. Res Rep Health Eff Inst :7-27; discussion 95-109
Yang, C S; Chhabra, S K; Hong, J Y et al. (2001) Mechanisms of inhibition of chemical toxicity and carcinogenesis by diallyl sulfide (DAS) and related compounds from garlic. J Nutr 131:1041S-5S
Yang, C S (2001) Inhibition of carcinogenesis and toxicity by dietary constituents. Adv Exp Med Biol 500:541-50
Smith, T J; Yang, C S (2000) Effect of organosulfur compounds from garlic and cruciferous vegetables on drug metabolism enzymes. Drug Metabol Drug Interact 17:23-49
Chen, L; Hong, J Y; So, E et al. (1999) Decrease of hepatic catalase level by treatment with diallyl sulfide and garlic homogenates in rats and mice. J Biochem Mol Toxicol 13:127-34
Bondoc, F Y; Bao, Z; Hu, W Y et al. (1999) Acetone catabolism by cytochrome P450 2E1: studies with CYP2E1-null mice. Biochem Pharmacol 58:461-3
Hong, J Y; Wang, Y Y; Bondoc, F Y et al. (1999) Metabolism of methyl tert-butyl ether and other gasoline ethers in mouse liver microsomes lacking cytochrome P450 2E1. Toxicol Lett 105:83-8
Hu, J J; Hong, J Y; Lea, M A et al. (1998) Differential expression of cytochrome P4502E1 (CYP2E1) in Morris hepatomas and livers of tumor bearing rats. Int J Oncol 12:1049-53
Hong, J Y; Yang, C S; Lee, M et al. (1997) Role of cytochromes P450 in the metabolism of methyl tert-butyl ether in human livers. Arch Toxicol 71:266-9
Tan, Y; White, S P; Paranawithana, S R et al. (1997) A hypothetical model for the active site of human cytochrome P4502E1. Xenobiotica 27:287-99

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