Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES003953-11
Application #
2153493
Study Section
Chemical Pathology Study Section (CPA)
Project Start
1985-12-06
Project End
1997-05-31
Budget Start
1996-02-01
Budget End
1997-05-31
Support Year
11
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Missouri-Columbia
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
112205955
City
Columbia
State
MO
Country
United States
Zip Code
65211
Loeppky, Richard N; Sukhtankar, Sunil; Gu, Feng et al. (2005) The carcinogenic significance of reactive intermediates derived from 3-acetoxy- and 5-acetoxy-2-hydroxy-N-nitrosomorpholine. Chem Res Toxicol 18:1955-66
Loeppky, Richard N; Ye, Qiuping; Goelzer, Petra et al. (2002) DNA adducts from N-nitrosodiethanolamine and related beta-oxidized nitrosamines in vivo: (32)P-postlabeling methods for glyoxal- and O(6)-hydroxyethyldeoxyguanosine adducts. Chem Res Toxicol 15:470-82
Loeppky, Richard N; Goelzer, Petra (2002) Microsome-mediated oxidation of N-nitrosodiethanolamine (NDELA), a bident carcinogen. Chem Res Toxicol 15:457-69
Park, M; Loeppky, R N (2000) In vitro DNA deamination by alpha-nitrosaminoaldehydes determined by GC/MS-SIM quantitation. Chem Res Toxicol 13:72-81
Loeppky, R N (1999) The mechanism of bioactivation of N-nitrosodiethanolamine. Drug Metab Rev 31:175-93
Loeppky, R N; Fuchs, A; Janzowski, C et al. (1998) Probing the mechanism of the carcinogenic activation of N-nitrosodiethanolamine with deuterium isotope effects: in vivo induction of DNA single-strand breaks and related in vitro assays. Chem Res Toxicol 11:1556-66
Loeppky, R N; Srinivasan, A (1995) Thiol oxidation by 1,2,3-oxadiazolinium ions, presumed carcinogens. Chem Res Toxicol 8:817-20
Loeppky, R N; Lee, M P; Muller, S (1994) Modification of DNA by alpha-nitrosamino aldehydes. IARC Sci Publ :429-32
Loeppky, R N; Li, E (1988) Diazonium ion derived products from the Ce(IV) oxidation of beta-hydroxy nitrosamines. Chem Res Toxicol 1:334-6