Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES004203-09
Application #
2153609
Study Section
Chemical Pathology Study Section (CPA)
Project Start
1987-08-01
Project End
1997-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
9
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Cincinnati
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
City
Cincinnati
State
OH
Country
United States
Zip Code
45221

  Publications

Talaska, Glenn; Ginsburg, David; LaDow, Kathy et al. (2006) Impact of Cyp1a2 or Ahr gene knockout in mice: implications for biomonitoring studies. Toxicol Lett 162:246-9
Xue, Weiling; Warshawsky, David (2005) Metabolic activation of polycyclic and heterocyclic aromatic hydrocarbons and DNA damage: a review. Toxicol Appl Pharmacol 206:73-93
O'Brien, T; Schneider, J; Warshawsky, D et al. (2002) In vitro toxicity of 7H-dibenzo[c,g]carbazole in human liver cell lines. Toxicol In Vitro 16:235-43
Xue, Weiling; Siner, Angela; Rance, Mark et al. (2002) A metabolic activation mechanism of 7H-dibenzo[c,g]carbazole via o-quinone. Part 2: covalent adducts of 7H-dibenzo[c,g]carbazole-3,4-dione with nucleic acid bases and nucleosides. Chem Res Toxicol 15:915-21
Gray, D L; Warshawsky, D; Xue, W et al. (2001) The effects of a binary mixture of benzo(a)pyrene and 7H-dibenzo(c,g)carbazole on lung tumors and K-ras oncogene mutations in strain A/J mice. Exp Lung Res 27:245-53
Mitchell, K R; Warshawsky, D (2001) Comparison of Ha-ras mutational spectra of N-methyldibenzo[c,g]carbazole and 7H-dibenzo[c,g]carbazole-induced mouse skin tumors. Mol Carcinog 32:55-60
Xue, W; Schneider, J; Mitchell, K et al. (2001) trans-3,4-dihydroxy-anti-1,2-epoxy-1,2,3,4-tetrahydrodi- benz[a,j]acridine involvement in dibenz[a,j]acridine DNA adduct formation in mouse skin consistent with Ha-ras mutation patterns in tumors. Chem Res Toxicol 14:871-8
Dowty, H V; Xue, W; LaDow, K et al. (2000) One-electron oxidation is not a major route of metabolic activation and DNA binding for the carcinogen 7H-dibenzo[c,g]carbazole in vitro and in mouse liver and lung. Carcinogenesis 21:991-8
O'Brien, T; Babcock, G; Cornelius, J et al. (2000) A comparison of apoptosis and necrosis induced by hepatotoxins in HepG2 cells. Toxicol Appl Pharmacol 164:280-90
Mitchell, K R; Warshawsky, D (1999) Frequent Ha-ras mutations in murine skin and liver tumors induced by 7H-dibenzo[c,g]carbazole. Mol Carcinog 25:107-12

Showing the most recent 10 out of 27 publications