Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
2R01ES004344-06A4
Application #
2153661
Study Section
Toxicology Subcommittee 2 (TOX)
Project Start
1988-01-15
Project End
2001-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Louisiana State University Hsc New Orleans
Department
Pharmacology
Type
Schools of Medicine
DUNS #
782627814
City
New Orleans
State
LA
Country
United States
Zip Code
70112

  Publications

Connick, J Patrick; Reed, James R; Backes, Wayne L (2018) Characterization of Interactions Among CYP1A2, CYP2B4, and NADPH-cytochrome P450 Reductase: Identification of Specific Protein Complexes. Drug Metab Dispos 46:197-203
Reed, James R; Backes, Wayne L (2017) Physical Studies of P450-P450 Interactions: Predicting Quaternary Structures of P450 Complexes in Membranes from Their X-ray Crystal Structures. Front Pharmacol 8:28
Brignac-Huber, Lauren M; Park, Ji Won; Reed, James R et al. (2016) Cytochrome P450 Organization and Function Are Modulated by Endoplasmic Reticulum Phospholipid Heterogeneity. Drug Metab Dispos 44:1859-1866
Reed, James R; Backes, Wayne L (2016) The functional effects of physical interactions involving cytochromes P450: putative mechanisms of action and the extent of these effects in biological membranes. Drug Metab Rev 48:453-69
Scott, Emily E; Wolf, C Roland; Otyepka, Michal et al. (2016) The Role of Protein-Protein and Protein-Membrane Interactions on P450 Function. Drug Metab Dispos 44:576-90
Park, Ji Won; Reed, James R; Backes, Wayne L (2015) The Localization of Cytochrome P450s CYP1A1 and CYP1A2 into Different Lipid Microdomains Is Governed by Their N-terminal and Internal Protein Regions. J Biol Chem 290:29449-60
Reed, James R; dela Cruz, Albert Leo N; Lomnicki, Slawo M et al. (2015) Environmentally persistent free radical-containing particulate matter competitively inhibits metabolism by cytochrome P450 1A2. Toxicol Appl Pharmacol 289:223-30
Reed, James R; dela Cruz, Albert Leo N; Lomnicki, Slawo M et al. (2015) Inhibition of cytochrome P450 2B4 by environmentally persistent free radical-containing particulate matter. Biochem Pharmacol 95:126-32
Park, Ji Won; Reed, James R; Brignac-Huber, Lauren M et al. (2014) Cytochrome P450 system proteins reside in different regions of the endoplasmic reticulum. Biochem J 464:241-9
Johnson, Eric F; Connick, J Patrick; Reed, James R et al. (2014) Correlating structure and function of drug-metabolizing enzymes: progress and ongoing challenges. Drug Metab Dispos 42:9-22

Showing the most recent 10 out of 39 publications