Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
2R01ES005304-06
Application #
2154045
Study Section
Toxicology Subcommittee 2 (TOX)
Project Start
1990-01-01
Project End
1998-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
George Washington University
Department
Pharmacology
Type
Schools of Medicine
DUNS #
City
Washington
State
DC
Country
United States
Zip Code
20052

  Publications

Nickens, Kristen P; Wikstrom, Jakob D; Shirihai, Orian S et al. (2013) A bioenergetic profile of non-transformed fibroblasts uncovers a link between death-resistance and enhanced spare respiratory capacity. Mitochondrion 13:662-7
Kost, Gina Chun; Patierno, Steven R; Wise, Sandra S et al. (2012) Protein tyrosine phosphatase (PTP) inhibition enhances chromosomal stability after genotoxic stress: decreased chromosomal instability (CIN) at the expense of enhanced genomic instability (GIN)? Mutat Res 735:51-5
Nickens, Kristen P; Han, Ying; Shandilya, Harini et al. (2012) Acquisition of mitochondrial dysregulation and resistance to mitochondrial-mediated apoptosis after genotoxic insult in normal human fibroblasts: a possible model for early stage carcinogenesis. Biochim Biophys Acta 1823:264-72
Nickens, Kristen P; Patierno, Steven R; Ceryak, Susan (2010) Chromium genotoxicity: A double-edged sword. Chem Biol Interact 188:276-88
LaCerte, Carolyne; Xie, Hong; Aboueissa, AbouEl-Makarim et al. (2010) Particulate depleted uranium is cytotoxic and clastogenic to human lung epithelial cells. Mutat Res 697:33-7
Bae, Dongsoon; Camilli, Tura C; Chun, Gina et al. (2009) Bypass of hexavalent chromium-induced growth arrest by a protein tyrosine phosphatase inhibitor: enhanced survival and mutagenesis. Mutat Res 660:40-6
Beaver, Laura M; Stemmy, Erik J; Constant, Stephanie L et al. (2009) Lung injury, inflammation and Akt signaling following inhalation of particulate hexavalent chromium. Toxicol Appl Pharmacol 235:47-56
Beaver, Laura M; Stemmy, Erik J; Schwartz, Arnold M et al. (2009) Lung inflammation, injury, and proliferative response after repetitive particulate hexavalent chromium exposure. Environ Health Perspect 117:1896-902
O'Brien, Travis J; Witcher, Preston; Brooks, Bradford et al. (2009) DNA polymerase zeta is essential for hexavalent chromium-induced mutagenesis. Mutat Res 663:77-83
Xu, Jian; Manning, Francis C R; O'Brien, Travis J et al. (2004) Mechanisms of chromium-induced suppression of RNA synthesis in cellular and cell-free systems: relationship to RNA polymerase arrest. Mol Cell Biochem 255:151-60

Showing the most recent 10 out of 29 publications