Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES005780-09
Application #
2154652
Study Section
Chemical Pathology Study Section (CPA)
Project Start
1991-05-01
Project End
1999-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
9
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Washington
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Gross-Steinmeyer, Kerstin; Stapleton, Patricia L; Tracy, Julia H et al. (2010) Sulforaphane- and phenethyl isothiocyanate-induced inhibition of aflatoxin B1-mediated genotoxicity in human hepatocytes: role of GSTM1 genotype and CYP3A4 gene expression. Toxicol Sci 116:422-32
Gross-Steinmeyer, Kerstin; Stapleton, Patricia L; Tracy, Julia H et al. (2009) Modulation of aflatoxin B1-mediated genotoxicity in primary cultures of human hepatocytes by diindolylmethane, curcumin, and xanthohumols. Toxicol Sci 112:303-10
Zhou, Changcheng; Poulton, Emma-Jane; Grun, Felix et al. (2007) The dietary isothiocyanate sulforaphane is an antagonist of the human steroid and xenobiotic nuclear receptor. Mol Pharmacol 71:220-9
Peterson, Sabrina; Lampe, Johanna W; Bammler, Theo K et al. (2006) Apiaceous vegetable constituents inhibit human cytochrome P-450 1A2 (hCYP1A2) activity and hCYP1A2-mediated mutagenicity of aflatoxin B1. Food Chem Toxicol 44:1474-84
Guo, Yingying; Breeden, Linda L; Fan, Wenhong et al. (2006) Analysis of cellular responses to aflatoxin B(1) in yeast expressing human cytochrome P450 1A2 using cDNA microarrays. Mutat Res 593:121-42
Gross-Steinmeyer, K; Stapleton, P L; Tracy, J H et al. (2005) Influence of Matrigel-overlay on constitutive and inducible expression of nine genes encoding drug-metabolizing enzymes in primary human hepatocytes. Xenobiotica 35:419-38
Guo, Yingying; Breeden, Linda L; Zarbl, Helmut et al. (2005) Expression of a human cytochrome p450 in yeast permits analysis of pathways for response to and repair of aflatoxin-induced DNA damage. Mol Cell Biol 25:5823-33
Abel, Erika L; Bammler, Theo K; Eaton, David L (2004) Biotransformation of methyl parathion by glutathione S-transferases. Toxicol Sci 79:224-32
Abel, Erika L; Lyon, Robert P; Bammler, Theodore K et al. (2004) Estradiol metabolites as isoform-specific inhibitors of human glutathione S-transferases. Chem Biol Interact 151:21-32
Gross-Steinmeyer, K; Stapleton, P L; Liu, F et al. (2004) Phytochemical-induced changes in gene expression of carcinogen-metabolizing enzymes in cultured human primary hepatocytes. Xenobiotica 34:619-32

Showing the most recent 10 out of 18 publications