Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES006288-05
Application #
2155167
Study Section
Metabolic Pathology Study Section (MEP)
Project Start
1992-09-29
Project End
1998-08-31
Budget Start
1996-09-01
Budget End
1998-08-31
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Fontes, Aparecida Maria; Davis, Brian M; Encell, Lance P et al. (2006) Differential competitive resistance to methylating versus chloroethylating agents among five O6-alkylguanine DNA alkyltransferases in human hematopoietic cells. Mol Cancer Ther 5:121-8
Zielske, Steven P; Lingas, Karen T; Li, Yan et al. (2004) Limited lentiviral transgene expression with increasing copy number in an MGMT selection model: lack of copy number selection by drug treatment. Mol Ther 9:923-31
Vollweiler, J L; Zielske, S P; Reese, J S et al. (2003) Hematopoietic stem cell gene therapy: progress toward therapeutic targets. Bone Marrow Transplant 32:1-7
Zielske, Steven P; Gerson, Stanton L (2003) Cytokines, including stem cell factor alone, enhance lentiviral transduction in nondividing human LTCIC and NOD/SCID repopulating cells. Mol Ther 7:325-33
Zielske, Steven P; Reese, Jane S; Lingas, Karen T et al. (2003) In vivo selection of MGMT(P140K) lentivirus-transduced human NOD/SCID repopulating cells without pretransplant irradiation conditioning. J Clin Invest 112:1561-70
Zielske, Steven P; Gerson, Stanton L (2003) SarCNU mediates selection of P140K methylguanine-DNA-methyltransferase transduced human CD34(+) cells in vitro. Blood Cells Mol Dis 31:48-50
Reese, Jane S; Liu, Lili; Gerson, Stanton L (2003) Repopulating defect of mismatch repair-deficient hematopoietic stem cells. Blood 102:1626-33
Bowman, Janice E; Reese, Jane S; Lingas, Karen T et al. (2003) Myeloablation is not required to select and maintain expression of the drug-resistance gene, mutant MGMT, in primary and secondary recipients. Mol Ther 8:42-50
Liu, Lili; Schwartz, Stuart; Davis, Brian M et al. (2002) Chemotherapy-induced O(6)-benzylguanine-resistant alkyltransferase mutations in mismatch-deficient colon cancer. Cancer Res 62:3070-6
Wadhwa, Punit D; Zielske, Steven P; Roth, Justin C et al. (2002) Cancer gene therapy: scientific basis. Annu Rev Med 53:437-52

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