Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
3R01ES007355-03S1
Application #
2614235
Study Section
Toxicology Subcommittee 2 (TOX)
Project Start
1995-04-01
Project End
1999-03-31
Budget Start
1997-04-01
Budget End
1999-03-31
Support Year
3
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of Florida
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
073130411
City
Gainesville
State
FL
Country
United States
Zip Code
32611
Mangal, Naveen; James, Margaret O; Stacpoole, Peter W et al. (2018) Model Informed Dose Optimization of Dichloroacetate for the Treatment of Congenital Lactic Acidosis in Children. J Clin Pharmacol 58:212-220
Shroads, A L; Coats, B S; McDonough, C W et al. (2015) Haplotype variations in glutathione transferase zeta 1 influence the kinetics and dynamics of chronic dichloroacetate in children. J Clin Pharmacol 55:50-5
Langaee, Taimour Y; Zhong, Guo; Li, Wenjun et al. (2015) The influence of human GSTZ1 gene haplotype variations on GSTZ1 expression. Pharmacogenet Genomics 25:239-45
Li, Wenjun; Gu, Yuan; James, Margaret O et al. (2012) Prenatal and postnatal expression of glutathione transferase ? 1 in human liver and the roles of haplotype and subject age in determining activity with dichloroacetate. Drug Metab Dispos 40:232-9
Shroads, Albert L; Langaee, Taimour; Coats, Bonnie S et al. (2012) Human polymorphisms in the glutathione transferase zeta 1/maleylacetoacetate isomerase gene influence the toxicokinetics of dichloroacetate. J Clin Pharmacol 52:837-49
Landgraf, Rachelle R; Garrett, Timothy J; Conaway, Maria C Prieto et al. (2011) Considerations for quantification of lipids in nerve tissue using matrix-assisted laser desorption/ionization mass spectrometric imaging. Rapid Commun Mass Spectrom 25:3178-84
Stacpoole, Peter W (2011) The dichloroacetate dilemma: environmental hazard versus therapeutic goldmine--both or neither? Environ Health Perspect 119:155-8
Garrett, Timothy J; Merves, Matthew; Yost, Richard A (2011) Characterization of protonated phospholipids as fragile ions in quadrupole ion trap mass spectrometry. Int J Mass Spectrom 308:299-306
Li, Wenjun; James, Margaret O; McKenzie, Sarah C et al. (2011) Mitochondrion as a novel site of dichloroacetate biotransformation by glutathione transferase zeta 1. J Pharmacol Exp Ther 336:87-94
Garrett, Timothy J; Yost, Richard A (2010) Tandem mass spectrometric methods for phospholipid analysis from brain tissue. Methods Mol Biol 656:209-30

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