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Hu, Jinping; Sheng, Li; Li, Lei et al. (2014) Essential role of the cytochrome P450 enzyme CYP2A5 in olfactory mucosal toxicity of naphthalene. Drug Metab Dispos 42:23-7
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Xie, Fang; Fang, Cheng; Schnittke, Nikolai et al. (2013) Mechanisms of permanent loss of olfactory receptor neurons induced by the herbicide 2,6-dichlorobenzonitrile: effects on stem cells and noninvolvement of acute induction of the inflammatory cytokine IL-6. Toxicol Appl Pharmacol 272:598-607
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Xie, Fang; D'Agostino, Jaime; Zhou, Xin et al. (2013) Bioactivation of the nasal toxicant 2,6-dichlorobenzonitrile: an assessment of metabolic activity in human nasal mucosa and identification of indicators of exposure and potential toxicity. Chem Res Toxicol 26:388-98
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Wei, Yuan; Li, Lei; Zhou, Xin et al. (2013) Generation and characterization of a novel Cyp2a(4/5)bgs-null mouse model. Drug Metab Dispos 41:132-40
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Riddick, David S; Ding, Xinxin; Wolf, C Roland et al. (2013) NADPH-cytochrome P450 oxidoreductase: roles in physiology, pharmacology, and toxicology. Drug Metab Dispos 41:12-23
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Wei, Yuan; Wu, Hong; Li, Lei et al. (2012) Generation and characterization of a CYP2A13/2B6/2F1-transgenic mouse model. Drug Metab Dispos 40:1144-50
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Fang, C; Bolivar, V J; Gu, J et al. (2012) Neurobehavioral abnormalities in a brain-specific NADPH-cytochrome P450 reductase knockout mouse model. Neuroscience 218:170-80
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Zhou, Xin; D'Agostino, Jaime; Li, Lei et al. (2012) Respective roles of CYP2A5 and CYP2F2 in the bioactivation of 3-methylindole in mouse olfactory mucosa and lung: studies using Cyp2a5-null and Cyp2f2-null mouse models. Drug Metab Dispos 40:642-7
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Xie, Fang; Zhou, Xin; Genter, Mary Beth et al. (2011) The tissue-specific toxicity of methimazole in the mouse olfactory mucosa is partly mediated through target-tissue metabolic activation by CYP2A5. Drug Metab Dispos 39:947-51
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Zhou, Xin; Wei, Yuan; Xie, Fang et al. (2011) A novel defensive mechanism against acetaminophen toxicity in the mouse lateral nasal gland: role of CYP2A5-mediated regulation of testosterone homeostasis and salivary androgen-binding protein expression. Mol Pharmacol 79:710-23
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