Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES007462-03
Application #
2156876
Study Section
Toxicology Subcommittee 2 (TOX)
Project Start
1994-09-15
Project End
1998-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Wadsworth Center
Department
Type
DUNS #
110521739
City
Menands
State
NY
Country
United States
Zip Code
12204
Hu, Jinping; Sheng, Li; Li, Lei et al. (2014) Essential role of the cytochrome P450 enzyme CYP2A5 in olfactory mucosal toxicity of naphthalene. Drug Metab Dispos 42:23-7
Xie, Fang; Fang, Cheng; Schnittke, Nikolai et al. (2013) Mechanisms of permanent loss of olfactory receptor neurons induced by the herbicide 2,6-dichlorobenzonitrile: effects on stem cells and noninvolvement of acute induction of the inflammatory cytokine IL-6. Toxicol Appl Pharmacol 272:598-607
Xie, Fang; D'Agostino, Jaime; Zhou, Xin et al. (2013) Bioactivation of the nasal toxicant 2,6-dichlorobenzonitrile: an assessment of metabolic activity in human nasal mucosa and identification of indicators of exposure and potential toxicity. Chem Res Toxicol 26:388-98
Wei, Yuan; Li, Lei; Zhou, Xin et al. (2013) Generation and characterization of a novel Cyp2a(4/5)bgs-null mouse model. Drug Metab Dispos 41:132-40
Riddick, David S; Ding, Xinxin; Wolf, C Roland et al. (2013) NADPH-cytochrome P450 oxidoreductase: roles in physiology, pharmacology, and toxicology. Drug Metab Dispos 41:12-23
Wei, Yuan; Wu, Hong; Li, Lei et al. (2012) Generation and characterization of a CYP2A13/2B6/2F1-transgenic mouse model. Drug Metab Dispos 40:1144-50
Fang, C; Bolivar, V J; Gu, J et al. (2012) Neurobehavioral abnormalities in a brain-specific NADPH-cytochrome P450 reductase knockout mouse model. Neuroscience 218:170-80
Zhou, Xin; D'Agostino, Jaime; Li, Lei et al. (2012) Respective roles of CYP2A5 and CYP2F2 in the bioactivation of 3-methylindole in mouse olfactory mucosa and lung: studies using Cyp2a5-null and Cyp2f2-null mouse models. Drug Metab Dispos 40:642-7
Zou, Ling; Li, Li; Porter, Todd D (2011) 7-Dehydrocholesterol reductase activity is independent of cytochrome P450 reductase. J Steroid Biochem Mol Biol 127:435-8
Gonzalez, Monika; Sealls, Whitney; Jesch, Elliot D et al. (2011) Defining a relationship between dietary fatty acids and the cytochrome P450 system in a mouse model of fatty liver disease. Physiol Genomics 43:121-35

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