Abstract

The main objective of the application is to better define the human health risks associated with prenatal and early postnatal exposure to methylmercury in fish. Subtle psychological and behavioral changes will be measured and related to the exposure of mothers during pregnancy. The study will be conducted on a cohort of 740 children from a population in the Seychelles Islands, whose diet consists primarily of large amounts of ocean fish. The application will extend the evaluation of developmental toxicity of methylmercury on the cohort to include the age of 7-8 years, which will make it feasible to compare results with those from studies of prenatally exposed infants in New Zealand and the Faeroe Islands. The population used in the longitudinal study presents a wide range in mercury levels so that the results can be applied in assessing the health risks in the U.S. population due to consumption of methylmercury in fish.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES008442-02
Application #
2749708
Study Section
Special Emphasis Panel (ZRG4-EDC-2 (01))
Project Start
1997-08-01
Project End
1999-07-31
Budget Start
1998-08-01
Budget End
1999-07-31
Support Year
2
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
University of Rochester
Department
Public Health & Prev Medicine
Type
Schools of Dentistry
DUNS #
208469486
City
Rochester
State
NY
Country
United States
Zip Code
14627

  Publications

Huang, Li-Shan; Cory-Slechta, Deborah A; Cox, Christopher et al. (2018) Analysis of Nonlinear Associations between Prenatal Methylmercury Exposure from Fish Consumption and Neurodevelopmental Outcomes in the Seychelles Main Cohort at 17 Years. Stoch Environ Res Risk Assess 32:893-904
van Wijngaarden, Edwin; Thurston, Sally W; Myers, Gary J et al. (2017) Methyl mercury exposure and neurodevelopmental outcomes in the Seychelles Child Development Study Main cohort at age 22 and 24years. Neurotoxicol Teratol 59:35-42
Love, Tanzy Mt; Thurston, Sally W; Davidson, Philip W (2017) Finding vulnerable subpopulations in the Seychelles Child Development Study: effect modification with latent groups. Stat Methods Med Res 26:809-822
Périard, Daniel; Beqiraj, Bujar; Hayoz, Daniel et al. (2015) Associations of baroreflex sensitivity, heart rate variability, and initial orthostatic hypotension with prenatal and recent postnatal methylmercury exposure in the Seychelles Child Development Study at age 19 years. Int J Environ Res Public Health 12:3395-405
Xiao, Luo; Thurston, Sally W; Ruppert, David et al. (2014) Bayesian Models for Multiple Outcomes in Domains with Application to the Seychelles Child Development Study. J Am Stat Assoc 109:1-10
van Wijngaarden, Edwin; Harrington, Donald; Kobrosly, Roni et al. (2014) Prenatal exposure to methylmercury and LCPUFA in relation to birth weight. Ann Epidemiol 24:273-8
Orlando, Mark S; Dziorny, Adam C; Harrington, Donald et al. (2014) Associations between prenatal and recent postnatal methylmercury exposure and auditory function at age 19 years in the Seychelles Child Development Study. Neurotoxicol Teratol 46:68-76
Watson, Gene E; van Wijngaarden, Edwin; Love, Tanzy M T et al. (2013) Neurodevelopmental outcomes at 5 years in children exposed prenatally to maternal dental amalgam: the Seychelles Child Development Nutrition Study. Neurotoxicol Teratol 39:57-62
Lyngdoh, Tanica; Viswanathan, Bharathi; Kobrosly, Roni et al. (2013) Blood pressure and cognitive function: a prospective analysis among adolescents in Seychelles. J Hypertens 31:1175-82
van Wijngaarden, Edwin; Davidson, Philip W; Smith, Tristram H et al. (2013) Autism spectrum disorder phenotypes and prenatal exposure to methylmercury. Epidemiology 24:651-9

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