Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES008457-02
Application #
2608522
Study Section
Special Emphasis Panel (ZRG2-ET-1 (04))
Project Start
1996-12-01
Project End
2000-11-30
Budget Start
1997-12-01
Budget End
1998-11-30
Support Year
2
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Texas Medical Br Galveston
Department
Type
Schools of Medicine
DUNS #
041367053
City
Galveston
State
TX
Country
United States
Zip Code
77555
Bhattacharyya, Asima; Chattopadhyay, Ranajoy; Mitra, Sankar et al. (2014) Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases. Physiol Rev 94:329-54
Sengupta, Shiladitya; Mitra, Sankar; Bhakat, Kishor K (2013) Dual regulatory roles of human AP-endonuclease (APE1/Ref-1) in CDKN1A/p21 expression. PLoS One 8:e68467
Hegde, Muralidhar L; Mantha, Anil K; Hazra, Tapas K et al. (2012) Oxidative genome damage and its repair: implications in aging and neurodegenerative diseases. Mech Ageing Dev 133:157-68
Mantha, Anil K; Dhiman, Monisha; Taglialatela, Giulio et al. (2012) Proteomic study of amyloid beta (25-35) peptide exposure to neuronal cells: Impact on APE1/Ref-1's protein-protein interaction. J Neurosci Res 90:1230-9
Sengupta, Shiladitya; Chattopadhyay, Ranajoy; Mantha, Anil K et al. (2012) Regulation of mouse-renin gene by apurinic/apyrimidinic-endonuclease 1 (APE1/Ref-1) via recruitment of histone deacetylase 1 corepressor complex. J Hypertens 30:917-25
Sengupta, S; Mantha, A K; Mitra, S et al. (2011) Human AP endonuclease (APE1/Ref-1) and its acetylation regulate YB-1-p300 recruitment and RNA polymerase II loading in the drug-induced activation of multidrug resistance gene MDR1. Oncogene 30:482-93
O'Hara, Ann M; Bhattacharyya, Asima; Bai, Jie et al. (2009) Tumor necrosis factor (TNF)-alpha-induced IL-8 expression in gastric epithelial cells: role of reactive oxygen species and AP endonuclease-1/redox factor (Ref)-1. Cytokine 46:359-69
Bhakat, Kishor K; Mantha, Anil K; Mitra, Sankar (2009) Transcriptional regulatory functions of mammalian AP-endonuclease (APE1/Ref-1), an essential multifunctional protein. Antioxid Redox Signal 11:621-38
Barnes, Tavish; Kim, Wan-Cheol; Mantha, Anil K et al. (2009) Identification of Apurinic/apyrimidinic endonuclease 1 (APE1) as the endoribonuclease that cleaves c-myc mRNA. Nucleic Acids Res 37:3946-58
Mantha, Anil K; Oezguen, Numan; Bhakat, Kishor K et al. (2008) Unusual role of a cysteine residue in substrate binding and activity of human AP-endonuclease 1. J Mol Biol 379:28-37

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